ArticleFrontiers in microbiology2023
The pathogenesis of zoonotic viral infections: Lessons learned by studying reservoir hosts.
Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Pathogen Access and Benefit-Sharing: Can the WHO Pandemic Agreement Bridge the Equity Divide?China CDC weekly · 2026Article
- Emerging and re-emerging vector-borne and other zoonotic RNA viruses: pathogenesis, climate-driven dynamics, and strategies for global control.Frontiers in microbiology · 2026Review
- Arthropod-borne disease challenges from planetary warming, urbanization, and migration.Virology journal · 2025Review
- Advancements and Challenges in Addressing Zoonotic Viral Infections with Epidemic and Pandemic Threats.Viruses · 2025Review
- An overview on H5N1 virus: Recent outbreaks and challenges.Bioinformation · 2025Article
- Modern agriculture and One Health.Infectious diseases of poverty · 2024Article
- Species-specific responses during Seoul orthohantavirus infection in human and rat lung microvascular endothelial cells.PLoS neglected tropical diseases · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zoonotic viral infections that cause severe disease or even death in some people may be asymptomatic or mild in reservoir hosts. Comparison of the pathogenesis of these two host categories may potentially explain the difference in disease. However, infections in reservoir hosts are often neglected. Therefore, we compared the pathogenesis of rabies virus, macacine alphaherpesvirus, West Nile virus, Puumala orthohantavirus, monkeypox virus, Lassa mammarenavirus, H5N1 highly pathogenic avian influenza, Marburg virus, Nipah virus, Middle East respiratory syndrome, and simian/human immunodeficiency viruses in both humans and reservoir hosts. We showed that most aspects of the pathogeneses were remarkably similar. The remaining differences lead to the identification of tipping points in the pathogeneses that are important for explaining the disease outcome in severe human cases. Further elucidating these tipping points by studying zoonotic viral infections in their reservoir hosts may teach us how to reduce the severity of zoonotic viral diseases in humans.
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