ArticleCureus2023
Inverse Correlation Between Bone Mineral Density and Systemic Immune Inflammation Index in Postmenopausal Turkish Women.
Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Association between immune-inflammatory index and osteoporosis: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Relationship between inflammatory indicators and bone mineral density in preschool children.Pediatric research · 2026Article
- Sarcopenia Versus Systemic Inflammation as Predictors of New Vertebral Fractures After Vertebroplasty or Kyphoplasty: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Article
- The relationship between inflammation, osteoporosis, and sleep disturbances: a cross-sectional analysis.European journal of medical research · 2025Article
- Associations between monocyte to HDL-C ratio and lumbar bone mineral density in alcohol dependent individuals with depression.Scientific reports · 2025Article
- Machine Learning-Based Interpretable Screening for Osteoporosis in Tuberculosis Spondylitis Patients Using Blood Test Data: Development and External Validation of a Novel Web-Based Risk Calculator with Explainable Artificial Intelligence (XAI).Infection and drug resistance · 2025Article
- Divergent associations of inflammatory markers with bone turnover markers in elderly patients with osteoporotic fractures.Scientific reports · 2024Article
- Correlation study: Bone density and circulating inflammatory markers in postmenopausal patients.Immunity, inflammation and disease · 2024Article
- Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic.Journal of cardiovascular development and disease · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIn this study, the correlation between the change in bone mineral density (BMD) and the numerical value of the systemic immune inflammation index (SII) in postmenopausal Turkish women was investigated. MATERIAL AND
methodsThe study comprised patients who had undergone menopause for at least one year and whose blood samples were examined by dual-energy X-ray absorptiometry (DEXA) on the same day. A retrospective evaluation of 527 postmenopausal women was performed. Age, body mass index (BMI), BMD,
resultsWhen the data were analyzed with the Statistical Package for the Social Sciences (SPSS; IBM SPSS Statistics for Windows, version 26.0. Armonk, NY: IBM Corp.), neutrophil (p<0.001), lymphocyte (p=0.004), monocytes (p=0.002), platelet distribution width (PDW) (p=0.02), procalcitonin (PCT) (p=0.04), erythrocyte sedimentation rate (ESR) (p=0.001), C-reactive protein (CRP) (p=0.001), NLR (p=0.001), PLR (p=0.004), MLR (p=0.003), and SII (p=0.001) values were found to be higher in the postmenopausal osteoporosis (PMO) group than in the normal and osteopenia groups (p<0.05). When the platelet (p=0.15), mean platelet volume (MPV) (p=0.07), and 25-OH vitamin-D (p=0.15) values were compared, no correlation was found between the groups (normal, osteopenia, and PMO) (p>0.05).
conclusionThis study revealed that NLR, PLR, MLR, and SII values were inversely correlated with the change in BMD in postmenopausal Turkish women. These biomarkers, which are obtained from a simple, affordable, and accessible routine blood examination, may play an effective role in the early diagnosis and prevention of PMO in the future.
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