Evidence map›Paper›PMID 37056207›Full record

ArticleJournal of Zhejiang University. Science. B2023

Short-chain fatty acids ameliorate spinal cord injury recovery by regulating the balance of regulatory T cells and effector IL-17

Pan Liu, Mingfu Liu, Deshuang Xi, Yiguang Bai, Ruixin Ma, Yaomin Mo, Gaofeng Zeng, Shaohui Zong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Pan LiuDepartment of Spine Osteopathic, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Mingfu LiuDepartment of Spine Osteopathic, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Deshuang XiDepartment of Spine Osteopathic, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Yiguang BaiDepartment of Spine Osteopathic, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Ruixin MaCollaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China.
Yaomin MoDepartment of Spine Osteopathic, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Gaofeng ZengCollege of Public Hygiene of Guangxi Medical University, Nanning 530021, China. fengfeng_388@126.com.
Shaohui ZongDepartment of Spine Osteopathic, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. xiaohui3008@126.com.
Guangxi Medical University · CNNorth Sichuan Medical University · CN

Funding

the Guangxi Medical High-level Key Talents Training "139" Program Training Project [2020]15the National Natural Science Foundation of China 82060399
6 · The paper itself

Abstract

Spinal cord injury (SCI) causes motor, sensory, and autonomic dysfunctions. The gut microbiome has an important role in SCI, while short-chain fatty acids (SCFAs) are one of the main bioactive mediators of microbiota. In the present study, we explored the effects of oral administration of exogenous SCFAs on the recovery of locomotor function and tissue repair in SCI. Allen's method was utilized to establish an SCI model in Sprague-Dawley (SD) rats. The animals received water containing a mixture of 150 mmol/L SCFAs after SCI. After 21 d of treatment, the Basso, Beattie, and Bresnahan (BBB) score increased, the regularity index improved, and the base of support (BOS) value declined. Spinal cord tissue inflammatory infiltration was alleviated, the spinal cord necrosis cavity was reduced, and the numbers of motor neurons and Nissl bodies were elevated. Enzyme-linked immunosorbent assay (ELISA), real-time quantitative polymerase chain reaction (qPCR), and immunohistochemistry assay revealed that the expression of interleukin (IL)‍-10 increased and that of IL-17 decreased in the spinal cord. SCFAs promoted gut homeostasis, induced intestinal T cells to shift toward an anti-inflammatory phenotype, and promoted regulatory T (Treg) cells to secrete IL-10, affecting Treg cells and IL-17

Indexed as

Spinal Cord InjuriesT-Lymphocytes, RegulatoryAnimalsInterleukin-17RatsRats, Sprague-DawleyReceptors, Antigen, T-Cell, gamma-deltaRecovery of FunctionInterleukin-17Receptors, Antigen, T-Cell, gamma-deltaIL-17+ γδ T cellsInflammationMotor function recoveryNeuroprotectionRegulatory T cellsShort-chain fatty acids (SCFAs)Spinal cord injury (SCI)

Identifiers

PMID37056207
PMCPMC10106403
OpenAlexW4365479297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.