Article in European psychiatry : the journal of the Association of European Psychiatrists, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Wenming Wei1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0003-1125-2732
Huijie Zhang1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Bolun Cheng1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0003-2915-5535
Xiaoyue Qin1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Dan He1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0002-6642-1882
Na Zhang1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0001-5290-4798
Yijing Zhao1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0002-1996-7831
Qingqing Cai1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0003-1083-7050
Sirong Shi1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0002-0288-2903
Xiaoge Chu1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0003-2710-1429
Yan Wen1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Huan Liu1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0002-6204-7993
Yumeng Jia1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0003-0060-9257
Feng Zhang1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education of China, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0003-1339-5956
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
objectiveGenetic approaches are increasingly advantageous in characterizing treatment-resistant schizophrenia (TRS). We aimed to identify TRS-associated functional brain proteins, providing a potential pathway for improving psychiatric classification and developing better-tailored therapeutic targets.
methodsTRS-related proteome-wide association studies (PWAS) were conducted on genome-wide association studies (GWAS) from CLOZUK and the Psychiatric Genomics Consortium (PGC), which provided TRS individuals (
resultsIn PWAS, two statistically significant proteins were identified using the ROS/MAP and then replicated using the Banner reference dataset, including CPT2 (
conclusionsOur results identified two protein biomarkers, and cautiously support that the pathological mechanism of TRS is linked to lipid oxidation and inflammation, where mitochondria-related functions may play a role.
Indexed as
SchizophreniaBrainGenome-Wide Association StudyHumansProteomeReactive Oxygen SpeciesSchizophrenia, Treatment-ResistantProteomeReactive Oxygen SpeciesHuman brain proteinsinflammationlipid oxidationmitochondriaproteome-wide association studytreatment-resistant schizophrenia
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Identification of novel functional brain proteins for treatment-resistant schizophrenia: Based on a proteome-wide association study. · full record | OpenQuestion