ArticleNature neuroscience2023
A reservoir of foraging decision variables in the mouse brain.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Learning to infer transitively on a mental line in premotor cortex.Science advances · 2026Article
- Neuromorphic tissues: Soft biomolecular networks for brain-inspired temporal computing.Science advances · 2026Article
- Adaptive reorganization of history encoding in the retrosplenial cortex supports flexible decision-making strategies.Neuron · 2026Article
- Cortex-wide characterization of decision-making neural dynamics during spatial navigation.Nature communications · 2026Article
- Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals.Nature communications · 2026Article
- Neural mechanisms of flexible perceptual inference.PLoS computational biology · 2025Article
- Contribution of amygdala to dynamic model arbitration under uncertainty.Nature communications · 2025Article
- Facial expressions in mice reveal latent cognitive variables and their neural correlates.Nature neuroscience · 2025Article
- Article
- Measuring and Controlling Solution Degeneracy across Task-Trained Recurrent Neural Networks.Advances in neural information processing systems · 2025Article
- Global neural encoding of behavioral strategies in mice during perceptual decision-making task with two different sensory patterns.iScience · 2024Article
- Sex mechanisms as nonbinary influences on cognitive diversity.Hormones and behavior · 2024Review
- Article
- Article
- Trial-history biases in evidence accumulation can give rise to apparent lapses in decision-making.Nature communications · 2024Article
- The maps of meaning consciousness theory.Frontiers in psychology · 2024Article
- The rat frontal orienting field dynamically encodes value for economic decisions under risk.Nature neuroscience · 2023Article
- Parallel processing of alternative approaches.Nature reviews. Neuroscience · 2023Article
- Decision-making dynamics are predicted by arousal and uninstructed movements.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In any given situation, the environment can be parsed in different ways to yield decision variables (DVs) defining strategies useful for different tasks. It is generally presumed that the brain only computes a single DV defining the current behavioral strategy. Here to test this assumption, we recorded neural ensembles in the frontal cortex of mice performing a foraging task admitting multiple DVs. Methods developed to uncover the currently employed DV revealed the use of multiple strategies and occasional switches in strategy within sessions. Optogenetic manipulations showed that the secondary motor cortex (M2) is needed for mice to use the different DVs in the task. Surprisingly, we found that regardless of which DV best explained the current behavior, M2 activity concurrently encoded a full basis set of computations defining a reservoir of DVs appropriate for alternative tasks. This form of neural multiplexing may confer considerable advantages for learning and adaptive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.