ArticleNature metabolism2023
The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions.
Article in Nature metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis.Nature metabolism · 2026Article
- Article
- Transcriptomic profiling of co-cultured cancer-host cells identifies hypoxia as a driver of the skeletal muscle cell's anti-proliferative effect on cancer cells.Oncogenesis · 2026Article
- Lactate-activated GPR81/FARP1 signaling drives insulin-independent glucose uptake and metabolic control.Cell research · 2026Article
- Acute effects of lactate infusion on metabolism, AD biomarkers, and cognition: The LEAN study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Brown adipose tissue activity impacts systemic lactate clearance in male mice.The Journal of physiology · 2025Article
- Mitochondrial uncoupling, energy substrate utilization, and brown adipose tissue as therapeutic targets in cancer.npj metabolic health and disease · 2025Review
- Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Male Mice Consuming Alcohol Attenuates Glycolysis.Nature communications · 2025Article
- Effects of lactate concentration on T-cell phenotype and mitochondrial respiration.Physiological reports · 2025Article
- Mechanism of Fatty Acid Metabolism and Regulation by Lactate During Exercise in White Adipose and Skeletal Muscle Tissue: A Review.Sports medicine - open · 2025Review
- Lactate orchestrates metabolic hemodynamic adaptations through a unique combination of venocontraction, artery relaxation, and positive inotropy.Acta physiologica (Oxford, England) · 2025Article
- Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis.Nature communications · 2025Article
- Lactate homeostasis is maintained through regulation of glycolysis and lipolysis.Cell metabolism · 2025Article
- Tandem metabolic reaction-based sensors unlock in vivo metabolomics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exercise-induced appetite suppression: An update on potential mechanisms.Physiological reports · 2024Review
- Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture.Nature communications · 2024Article
- The Role of Exerkines in Obesity-Induced Disruption of Mitochondrial Homeostasis in Thermogenic Fat.Metabolites · 2024Review
- Activation of GPR81 by lactate drives tumour-induced cachexia.Nature metabolism · 2024Article
- MCT1 helps brown fat suck up succinate.Nature metabolism · 2024Article
- Type 2 diabetes and succinate: unmasking an age-old molecule.Diabetologia · 2024Review
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Authors and funding
21 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactate is a circulating metabolite and a signalling molecule with pleiotropic physiological effects. Studies suggest that lactate modulates energy balance by lowering food intake, inducing adipose browning and increasing whole-body thermogenesis. Yet, like many other metabolites, lactate is often commercially produced as a counterion-bound salt and typically administered in vivo through hypertonic aqueous solutions of sodium L-lactate. Most studies have not controlled for injection osmolarity and the co-injected sodium ions. Here, we show that the anorectic and thermogenic effects of exogenous sodium L-lactate in male mice are confounded by the hypertonicity of the injected solutions. Our data reveal that this is in contrast to the antiobesity effect of orally administered disodium succinate, which is uncoupled from these confounders. Further, our studies with other counterions indicate that counterions can have confounding effects beyond lactate pharmacology. Together, these findings underscore the importance of controlling for osmotic load and counterions in metabolite research.
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