ArticleNature chemistry2023
Modular enantioselective access to β-amino amides by Brønsted acid-catalysed multicomponent reactions.
Article in Nature chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Synergistic Catalysis: Integrating Acids, Metals, and Light in Nature-Inspired Asymmetric Multicomponent Synthesis.Topics in current chemistry (Cham) · 2026Review
- Ag(I)/KThe Journal of organic chemistry · 2025Article
- Biomimetic 1,2-amino migration via photoredox catalysis.Nature chemistry · 2025Article
- βOrganic letters · 2024Article
- Integration of Wallach's Rule into Intermolecular Charge Transfer: A Visual Strategy for Chiral Purification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Ir/Zn-cocatalyzed chemo- and atroposelective [2+2+2] cycloaddition for construction of C─N axially chiral indoles and pyrroles.Science advances · 2023Article
- Amino amide assembly.Nature chemistry · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
β-Amino acids are structural motifs widely found in therapeutic natural products, novel biomimetic polymers and peptidomimetics. As a convergent method, the synthesis of stereoenriched β-amino amides through the asymmetric Mannich reaction requires specialized amide substrates or a metal catalyst for enolate formation. By a redesign of the Ugi reaction, a conceptually different solution to prepare chiral β-amino amides was established using ambiphilic ynamides as two-carbon synthons. The modulation of ynamides or oxygen nucleophiles concisely furnished three classes of β-amino amides with generally good efficiency as well as excellent chemo- and stereo-control. The utility is verified in the preparation of over 100 desired products that bear one or two contiguous carbon stereocentres, including those that directly incorporate drug molecules. This advance also provides a synthetic shortcut to other valuable structures. The amino amides could be elaborated into β-amino acids, anti-vicinal diamines, γ-amino alcohols and β-lactams or undergo transamidation with amino acids and amine-containing pharmaceuticals.
Identifiers
37055574What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.