ArticleNature plants2023
Study of vacuole glycerate transporter NPF8.4 reveals a new role of photorespiration in C/N balance.
Article in Nature plants, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 19 citations in OpenAlex.
- The mosaic of aquatic photorespiration: evolution, diversity, and global biogeochemical impacts.The New phytologist · 2026Review
- Post-Translational Control of Nitrate Reductase Under Elevated COPlants (Basel, Switzerland) · 2026Review
- Guard cell photorespiration controls stomata behavior and development.The New phytologist · 2026Article
- Reprogramming of Gene Transcripts and Metabolites by the Wild Soybean Endophyte Pseudomonas sp. 77S3 Improves Soybean Salt Tolerance.Plant biotechnology journal · 2026Article
- Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack.The New phytologist · 2026Review
- Shortcutting photorespiration: avenues and challenges toward realizing higher-yielding photorespiratory bypass crops.The New phytologist · 2026Review
- Combined transcriptome and metabolome analyses reveal that galactose metabolism is vital for tobacco in response to low-nitrate stress.Journal of genetics · 2026Article
- Interactive Effects of Light Intensity and Nitrogen Supply on Shoot Emergence and Associated Photosynthetic Traits inBiology · 2025Article
- Synthetic photorespiratory bypass improves rice productivity by enhancing photosynthesis and nitrogen uptake.The Plant cell · 2024Article
- Reactive oxygen species (ROS) modulate nitrogen signaling using temporal transcriptome analysis in foxtail millet.Plant molecular biology · 2024Article
- Multiple Roles of Glycerate Kinase-From Photorespiration to Gluconeogenesis, CInternational journal of molecular sciences · 2024Review
- Improved photorespiration has a major impact on the root metabolome of Arabidopsis.Physiologia plantarumArticle
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Abstract
The photorespiratory intermediate glycerate is known to be shuttled between the peroxisome and chloroplast. Here, localization of NPF8.4 in the tonoplast, together with the reduced vacuolar glycerate content displayed by an npf8.4 mutant and the glycerate efflux activity detected in an oocyte expression system, identifies NPF8.4 as a tonoplast glycerate influx transporter. Our study shows that expression of NPF8.4 and most photorespiration-associated genes, as well as the photorespiration rate, is upregulated in response to short-term nitrogen (N) depletion. We report growth retardation and early senescence phenotypes for npf8.4 mutants specifically upon N depletion, suggesting that the NPF8.4-mediated regulatory pathway for sequestering the photorespiratory carbon intermediate glycerate in vacuoles is important to alleviate the impact of an increased C/N ratio under N deficiency. Thus, our study of NPF8.4 reveals a novel role for photorespiration in N flux to cope with short-term N depletion.
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