Evidence map›Paper›PMID 37055506›Full record

ArticleLeukemia2023

Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner.

Mariusz Z Ratajczak, Mateusz Adamiak, Ahmed Abdelbaset-Ismail, Kamila Bujko, Arjun Thapa, Vira Chumak, Stephanie Franczak, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magdalena Kucia

Open access · hybridAbstract readLetter
In one paragraph

Article in Leukemia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 26 citations in OpenAlex.

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  11. Dual role of complement in neuronal repair.Frontiers in immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Mariusz Z RatajczakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA. mzrata01@louisville.edu.ORCID http://orcid.org/0000-0002-0071-0198
Mateusz AdamiakDepartment of Regenerative Medicine Warsaw Medical University, Warsaw, Poland.
Ahmed Abdelbaset-IsmailStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
Kamila BujkoDepartment of Regenerative Medicine Warsaw Medical University, Warsaw, Poland.ORCID http://orcid.org/0000-0002-2205-1154
Arjun ThapaStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
Vira ChumakDepartment of Regenerative Medicine Warsaw Medical University, Warsaw, Poland.
Stephanie FranczakDepartment of Regenerative Medicine Warsaw Medical University, Warsaw, Poland.
Katarzyna Brzezniakiewicz-JanusDepartment of Hematology, University of Zielona Gora, Hospital Gorzow Wlkp., Zielona Góra, Poland.ORCID http://orcid.org/0000-0002-4143-5778
Janina RatajczakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
Magdalena KuciaDepartment of Regenerative Medicine Warsaw Medical University, Warsaw, Poland.
Medical University of Warsaw · PLUniversity of Louisville · USUniversity of Zielona Góra · PL

Funding

Novel mechanisms involving complement cascade in stem cell traffickingR01DK074720 · NIDDK · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2007 to 2020
$4.1M
Current Trends in Stem Cell TherapiesT32HL134644 · NHLBI · UNIVERSITY OF LOUISVILLE · PI KAKAR, SHAM S., RATAJCZAK, MARIUSZ Z · 2017 to 2021
$1.4M
NHLBI NIH HHS T32 HL134644NIDDK NIH HHS 2R01 DK074720
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hematopoietic Stem CellsInflammasomesCell ProliferationComplement System ProteinsHumansComplement System ProteinsInflammasomes

Identifiers

PMID37055506
PMCPMC10244163
OpenAlexW4365451671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.