Evidence map›Paper›PMID 37055440›Full record

ArticleNPJ science of food2023

Obesity, but not high-fat diet, is associated with bone loss that is reversed via CD4

Wei Song, Qinglin Sheng, Yuying Bai, Li Li, Xin Ning, Yangeng Liu, Chen Song, Tianyi Wang, Xiaohua Dong, Yane Luo and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ science of food, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 5 countries.

Wei Song *College of Food Science and Technology, Northwest University, 710069, Xi'an, China. weisong2019@126.com.ORCID http://orcid.org/0000-0001-6696-1208
Qinglin Sheng *College of Food Science and Technology, Northwest University, 710069, Xi'an, China.
Yuying BaiSchool of Life Science and Technology, Tokyo Institute of Technology, 226-8501, Yokohama, Japan.
Li LiDepartment of Food Science and Technology, Harbin Institute of Technology, 150000, Harbin, China.
Xin NingDepartment of Food Science and Technology, Harbin Institute of Technology, 150000, Harbin, China.
Yangeng LiuDepartment of Food Science and Technology, Harbin Institute of Technology, 150000, Harbin, China.
Chen SongDepartment of Food Science and Technology, Harbin Institute of Technology, 150000, Harbin, China.
Tianyi WangDepartment of Food Science and Technology, Harbin Institute of Technology, 150000, Harbin, China.
Xiaohua DongDepartment of Food Science and Technology, Harbin Institute of Technology, 150000, Harbin, China.
Yane LuoCollege of Food Science and Technology, Northwest University, 710069, Xi'an, China.
Jinhong HuCollege of Food Science and Technology, Northwest University, 710069, Xi'an, China.
Lina ZhuCollege of Food Science and Technology, Northwest University, 710069, Xi'an, China.
Xiaole CuiCollege of Food Science and Technology, Northwest University, 710069, Xi'an, China.
Bing ChenCollege of Food Science and Technology, Northwest University, 710069, Xi'an, China.
Lingling LiCollege of Food Science and Technology, Northwest University, 710069, Xi'an, China.
Congli CaiCollege of Food Science and Technology, Northwest University, 710069, Xi'an, China.
Haobo CuiCollege of Food Science and Technology, Northwest University, 710069, Xi'an, China.
Tianli YueCollege of Food Science and Technology, Northwest University, 710069, Xi'an, China. yuetl@nwu.edu.cn.
Northwest University · CNHarbin Institute of Technology · CNTokyo Institute of Technology · JP

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31901701
6 · The paper itself

Abstract

Osteoporosis is characterized by decreased bone mass, microarchitectural deterioration, and increased bone fragility. High-fat diet (HFD)-induced obesity also results in bone loss, which is associated with an imbalanced gut microbiome. However, whether HFD-induced obesity or HFD itself promotes osteoclastogenesis and consequent bone loss remains unclear. In this study, we developed HFD-induced obesity (HIO) and non-obesity (NO) mouse models to evaluate the effect of HFD on bone loss. NO mice were defined as body weight within 5% of higher or lower than that of chow diet fed mice after 10 weeks HFD feeding. NO was protected from HIO-induced bone loss by the RANKL /OPG system, with associated increases in the tibia tenacity, cortical bone mean density, bone volume of cancellous bone, and trabecular number. This led to increased bone strength and improved bone microstructure via the microbiome-short-chain fatty acids (SCFAs) regulation. Additionally, endogenous gut-SCFAs produced by the NO mice activated free fatty acid receptor 2 and inhibited histone deacetylases, resulting in the promotion of Treg cell proliferation in the HFD-fed NO mice; thereby, inhibiting osteoclastogenesis, which can be transplanted by fecal microbiome. Furthermore, T cells from NO mice retain differentiation of osteoclast precursors of RAW 264.7 macrophages ex vivo. Our data reveal that HFD is not a deleterious diet; however, the induction of obesity serves as a key trigger of bone loss that can be blocked by a NO mouse-specific gut microbiome.

Identifiers

PMID37055440
PMCPMC10102288
OpenAlexW4365453712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.