ArticleNature communications2023
A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Generative AI as a transformational logic for cognitive neuroscience.Communications biology · 2026Review
- Sparse component analysis: A method that uncovers separable computations within neural population activity.Neuron · 2026Article
- Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation.eLife · 2026Article
- Re-emergence of orientation coding in primate IT cortex and deep networks reveals functional hubs for visual processing.bioRxiv : the preprint server for biology · 2026Article
- Millimeter-scale selective amplification in the developing visual cortex.bioRxiv : the preprint server for biology · 2026Article
- Cortex-wide characterization of decision-making neural dynamics during spatial navigation.Nature communications · 2026Article
- Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals.Nature communications · 2026Article
- Review
- Design principles for cost functions in optimal sensory coding.Frontiers in computational neuroscience · 2026Review
- Routing of task-relevant information in mouse PPC during continuous visuomotor control.bioRxiv : the preprint server for biology · 2025Article
- Parietal cortex is causally required for state-dependent decisions.Cell reports · 2025Article
- Specialized structure of neural population codes in parietal cortex outputs.Nature neuroscience · 2025Article
- Encoding of interdependent features of head direction and angular head velocity in navigation.PNAS nexus · 2025Article
- Parietal cortex is causally required for state-dependent decisions.bioRxiv : the preprint server for biology · 2025Article
- Precise Extraction of Neural Motifs Reveals Multiscale, Parallel Encoding Schemes in Auditory Cortex.bioRxiv : the preprint server for biology · 2025Article
- Cognitive processes are disentangled at cortex-wide scales.bioRxiv : the preprint server for biology · 2025Article
- MINT: A toolbox for the analysis of multivariate neural information coding and transmission.PLoS computational biology · 2025Article
- Basal Forebrain Projections to the Retrosplenial and Cingulate Cortex in Rats.The Journal of comparative neurology · 2025Article
- Nonresponsive Neurons Improve Population Coding of Object Location.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A transient high-dimensional geometry affords stable conjunctive subspaces for efficient action selection.Nature communications · 2024Article
Corrections and comments
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5 authors.
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Abstract
Decision-making requires flexibility to rapidly switch one's actions in response to sensory stimuli depending on information stored in memory. We identified cortical areas and neural activity patterns underlying this flexibility during virtual navigation, where mice switched navigation toward or away from a visual cue depending on its match to a remembered cue. Optogenetics screening identified V1, posterior parietal cortex (PPC), and retrosplenial cortex (RSC) as necessary for accurate decisions. Calcium imaging revealed neurons that can mediate rapid navigation switches by encoding a mixture of a current and remembered visual cue. These mixed selectivity neurons emerged through task learning and predicted the mouse's choices by forming efficient population codes before correct, but not incorrect, choices. They were distributed across posterior cortex, even V1, and were densest in RSC and sparsest in PPC. We propose flexibility in navigation decisions arises from neurons that mix visual and memory information within a visual-parietal-retrosplenial network.
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