Evidence map›Paper›PMID 37055366›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2023

Real-time prediction of intradialytic hypotension using machine learning and cloud computing infrastructure.

Hanjie Zhang, Lin-Chun Wang, Sheetal Chaudhuri, Aaron Pickering, Len Usvyat, John Larkin, Pete Waguespack, Zuwen Kuang, Jeroen P Kooman, Franklin W Maddux and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Hanjie ZhangRenal Research Institute, New York, NY, USA.
Lin-Chun WangRenal Research Institute, New York, NY, USA.
Sheetal ChaudhuriFresenius Medical Care, Global Medical Office, Waltham, MA, USA.
Aaron PickeringFresenius Medical Care, Data Solutions, Berlin, Germany.
Len UsvyatFresenius Medical Care, Global Medical Office, Waltham, MA, USA.
John LarkinFresenius Medical Care, Global Medical Office, Waltham, MA, USA.
Pete WaguespackFresenius Medical Care, Digital Technology & Innovation, Waltham, MA, USA.
Zuwen KuangFresenius Medical Care, Digital Technology & Innovation, Waltham, MA, USA.
Jeroen P KoomanMaastricht University Medical Center, Maastricht, The Netherlands.
Franklin W MadduxFresenius Medical Care, Global Medical Office, Waltham, MA, USA.
Peter KotankoRenal Research Institute, New York, NY, USA.
Fresenius Medical Care North America (United States)Renal Research Institute · USFresenius Medical Care (United States) · USFresenius Medical Care (Germany) · DEMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn maintenance hemodialysis patients, intradialytic hypotension (IDH) is a frequent complication that has been associated with poor clinical outcomes. Prediction of IDH may facilitate timely interventions and eventually reduce IDH rates.

methodsWe developed a machine learning model to predict IDH in in-center hemodialysis patients 15-75 min in advance. IDH was defined as systolic blood pressure (SBP) <90 mmHg. Demographic, clinical, treatment-related and laboratory data were retrieved from electronic health records and merged with intradialytic machine data that were sent in real-time to the cloud. For model development, dialysis sessions were randomly split into training (80%) and testing (20%) sets. The area under the receiver operating characteristic curve (AUROC) was used as a measure of the model's predictive performance.

resultsWe utilized data from 693 patients who contributed 42 656 hemodialysis sessions and 355 693 intradialytic SBP measurements. IDH occurred in 16.2% of hemodialysis treatments. Our model predicted IDH 15-75 min in advance with an AUROC of 0.89. Top IDH predictors were the most recent intradialytic SBP and IDH rate, as well as mean nadir SBP of the previous 10 dialysis sessions.

conclusionsReal-time prediction of IDH during an ongoing hemodialysis session is feasible and has a clinically actionable predictive performance. If and to what degree this predictive information facilitates the timely deployment of preventive interventions and translates into lower IDH rates and improved patient outcomes warrants prospective studies.

Indexed as

HypotensionKidney Failure, ChronicBlood PressureCloud ComputingHumansProspective StudiesRenal Dialysisend-stage kidney diseaseintradialytic hypotensionmachine learningreal-time prediction

Identifiers

PMID37055366
PMCPMC10310501
OpenAlexW4365458493

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.