Evidence map›Paper›PMID 37055300›Full record

ArticleDifferentiation; research in biological diversity

Characterizing the lens regeneration process in Pleurodeles waltl.

Georgios Tsissios, Gabriella Theodoroudis-Rapp, Weihao Chen, Anthony Sallese, Byran Smucker, Lake Ernst, Junfan Chen, Yiqi Xu, Sophia Ratvasky, Hui Wang and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Differentiation; research in biological diversity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Georgios TsissiosDepartment of Biology Miami University, Oxford, OH, USA; Center for Visual Sciences at Miami University, Oxford, OH, USA; Cellular Molecular and Structural Biology Program, Miami University, Oxford, OH, USA.
Gabriella Theodoroudis-RappDepartment of Biology Miami University, Oxford, OH, USA.
Weihao ChenCenter for Visual Sciences at Miami University, Oxford, OH, USA; Cellular Molecular and Structural Biology Program, Miami University, Oxford, OH, USA; Department of Chemical, Paper and Biomedical Engineering, Miami University, Oxford, OH, USA.
Anthony SalleseDepartment of Biology Miami University, Oxford, OH, USA; Center for Visual Sciences at Miami University, Oxford, OH, USA.
Byran SmuckerCenter for Visual Sciences at Miami University, Oxford, OH, USA; Department of Statistics, Miami University, Oxford, OH, USA.
Lake ErnstDepartment of Biology Miami University, Oxford, OH, USA.
Junfan ChenDepartment of Chemistry and Biochemistry, Miami University, Oxford, OH, USA.
Yiqi XuDepartment of Biology Miami University, Oxford, OH, USA.
Sophia RatvaskyDepartment of Biology Miami University, Oxford, OH, USA; Center for Visual Sciences at Miami University, Oxford, OH, USA; Cellular Molecular and Structural Biology Program, Miami University, Oxford, OH, USA.
Hui WangCenter for Visual Sciences at Miami University, Oxford, OH, USA; Department of Chemical, Paper and Biomedical Engineering, Miami University, Oxford, OH, USA.
Katia Del Rio-TsonisDepartment of Biology Miami University, Oxford, OH, USA; Center for Visual Sciences at Miami University, Oxford, OH, USA; Cellular Molecular and Structural Biology Program, Miami University, Oxford, OH, USA. Electronic address: delriok@miamioh.edu.
Miami University · US

Funding

On Determinants of Lens RegenerationR01EY027801 · NEI · MIAMI UNIVERSITY OXFORD · PI DEL RIO-TSONIS, KATIA · 2017 to 2019
$1.1M
In vivo imaging of newt lens regeneration: Novel molecular, cellular and functional insightsR21EY031865 · NEI · MIAMI UNIVERSITY OXFORD · PI DEL RIO-TSONIS, KATIA, WANG, HUI · 2020 to 2021
$383k
NEI NIH HHS R01 EY027801NEI NIH HHS R21 EY031865
6 · The paper itself

Abstract

backgroundAging and regeneration are heavily linked processes. While it is generally accepted that regenerative capacity declines with age, some vertebrates, such as newts, can bypass the deleterious effects of aging and successfully regenerate a lens throughout their lifetime.

resultsHere, we used Spectral-Domain Optical Coherence Tomography (SD-OCT) to monitor the lens regeneration process of larvae, juvenile, and adult newts. While all three life stages were able to regenerate a lens through transdifferentiation of the dorsal iris pigment epithelial cells (iPECs), an age-related change in the kinetics of the regeneration process was observed. Consistent with these findings, iPECs from older animals exhibited a delay in cell cycle re-entry. Furthermore, it was observed that clearance of the extracellular matrix (ECM) was delayed in older organisms.

conclusionsCollectively, our results suggest that although lens regeneration capacity does not decline throughout the lifespan of newts, the intrinsic and extrinsic cellular changes associated with aging alter the kinetics of this process. By understanding how these changes affect lens regeneration in newts, we can gain important insights for restoring the age-related regeneration decline observed in most vertebrates.

Indexed as

Lens, CrystallinePleurodelesAnimalsCell DivisionExtracellular MatrixSalamandridaeAgingCell cycleECM remodelingiPECsLens regenerationSD-OCT

Identifiers

PMID37055300
PMCPMC10493237
OpenAlexW4323923655

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.