Evidence map›Paper›PMID 37055179›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Multiple Subthreshold GPCR Signals Combined by the G-Proteins Gα

Andrew C Olson, Allison M Butt, Nakeirah T M Christie, Ashish Shelar, Michael R Koelle

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Rho signaling promotes cell excitability and synaptic transmission.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Review
  5. TheThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrew C OlsonDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510.
Allison M ButtDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510.
Nakeirah T M ChristieDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510.
Ashish ShelarDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510.
Michael R KoelleDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510 michael.koelle@yale.edu.ORCID 0000-0001-9486-8481
Yale University · US

Funding

G PROTEIN SIGNALING IN THE C ELEGANS NERVOUS SYSTEMR01NS036918 · NINDS · YALE UNIVERSITY · PI KOELLE, MICHAEL R · 1998 to 2019
$8.0M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Neuromodulator signaling and activity in the C. elegans egg-laying circuit.R01NS086932 · NINDS · YALE UNIVERSITY · PI Kevin Michael Collins, MICHAEL R KOELLE · 2014 to 2026
$5.2M
A swept-field confocal microscope for live cell imagingS10OD023598 · OD · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2017 to 2017
$570k
NIH HHS P40 OD010440NIH HHS S10 OD023598NINDS NIH HHS R01 NS036918NINDS NIH HHS R01 NS086932
6 · The paper itself

Abstract

Individual neurons or muscle cells express many G-protein-coupled receptors (GPCRs) for neurotransmitters and neuropeptides, yet it remains unclear how cells integrate multiple GPCR signals that all must activate the same few G-proteins. We analyzed this issue in the

Indexed as

Caenorhabditis elegansSerotoninAnimalsGTP-Binding ProteinsMuscle CellsMusclesGTP-Binding ProteinsSerotoninC. elegansGPCRG-proteinneuroscienceserotonin

Identifiers

PMID37055179
PMCPMC10219013
OpenAlexW4365445836

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.