ArticleNeuroscience2023
Influence of Strenuous Physical Activity and Cardiorespiratory Fitness on Age-Related Differences in Brain Activations During Varieties of Cognitive Control.
Article in Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Exercise Modulates Working Memory-Related Brain Activation Through Bidirectional Neural Mechanisms: An ALE Meta-Analysis of Longitudinal and Cross-Sectional fMRI Studies.Brain sciences · 2026Review
- Role of Exercise in Modulating the Brain-Heart Axis in Cardiovascular Diseases.International journal of molecular sciences · 2026Review
- Can the Components of Physical Fitness Be Linked to Creative Thinking and Fluid Intelligence in Spanish Schoolchildren?Healthcare (Basel, Switzerland) · 2025Article
- Neurophysiological mechanisms underlying cardiovascular adaptations to exercise: A narrative review.Physiological reports · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
While there is extensive literature on the beneficial effects of physical activity on age differences in cognitive control, limited research exists on comparing the contributions of strenuous physical activity (sPA) and cardiorespiratory fitness (CRF) to fluctuations in the blood oxygen level-dependent (BOLD) signals during varieties of cognitive control. The current study addresses this gap in knowledge by investigating BOLD signal differences between high-fit and low-fit older adults, determined by their sPA or CRF, during a novel fMRI task with a hybrid block and event-related design that included transient activations (during switching, updating and their combination trials) and sustained activations (during proactive and reactive control blocks). fBOLD signals from older (n = 25) were compared to more functionally efficient younger (n = 15) adults. High-sPA old showed higher task accuracy than Low-sPA old and similar accuracy as young. Whole-brain fMRI analyses identified higher BOLD activations (esp. dlPFC/MFG) in high-fit old during updating and combination trials that were similar to young, suggesting maintenance of BOLD signals in higher fit older adults during working memory updating. Additionally, both High-sPA and High-CRF related compensatory overactivation were observed in left parietal and occipital areas during sustained activations, which were positively correlated with older adults' accuracy. These results suggest that physical fitness is a modifier of age-related changes in BOLD signal modulation elicited in response to increasing cognitive control demands, with higher fitness in old contributing to both compensatory overactivations and maintenance of task-related brain activations during cognitive control, whereas lower fitness contributed to maladaptive overactivations during lower cognitive demands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.