Evidence map›Paper›PMID 37054846›Full record

ArticleChemosphere2023

Stress exposure histories revealed by biochemical changes along accentuated lines in teeth.

Christine Austin, Piyush Kumar, Elizabeth A Carter, Joonsup Lee, Tanya M Smith, Katie Hinde, Manish Arora, Peter A Lay

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemosphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Water, Soil, Noise, and Light Pollution: JACC Focus Seminar, Part 2.Journal of the American College of Cardiology · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Christine AustinSenator Frank R. Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: christine.austin@mssm.edu.
Piyush KumarSenator Frank R. Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Elizabeth A CarterSydney Analytical, The University of Sydney, Sydney, New South Wales, 2006, Australia; School of Chemistry, The University of Sydney, Sydney, New South Wales, 2006, Australia.
Joonsup LeeSydney Analytical, The University of Sydney, Sydney, New South Wales, 2006, Australia; School of Chemistry, The University of Sydney, Sydney, New South Wales, 2006, Australia.
Tanya M SmithAustralian Research Centre for Human Evolution, Griffith University, 170 Kessels Road, Nathan, Queensland, 4111, Australia; Griffith Centre for Social and Cultural Research, Parklands Drive, Southport, Queensland, 4222, Australia.
Katie HindeSchool of Human Evolution and Social Change, Arizona State University, Tempe, AZ, 85281, USA; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, 85281, USA.
Manish AroraSenator Frank R. Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Peter A LaySydney Analytical, The University of Sydney, Sydney, New South Wales, 2006, Australia; School of Chemistry, The University of Sydney, Sydney, New South Wales, 2006, Australia.
Icahn School of Medicine at Mount Sinai · USThe University of Sydney · AUArizona State University · USGriffith University · AU

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
ZONA PELLUCIDA PEPTIDES AS IMMUNOCONTRACEPTIVE ANTIGENSP51RR000169 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI HORTON, JONATHON C · 1985 to 2011
$126.2M
Reconstructing fetal toxicant exposure and homeostatic disruptionsDP2ES025453 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARORA, MANISH · 2014 to 2019
$2.6M
Early Life Environmental Toxicant Exposure and Oral HealthR00ES019597 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARORA, MANISH · 2013 to 2015
$747k
Determining the Neurodevelopmental Effects of Transition from Breastfeeding to Infant Formula using a Novel BiomarkerR00HD087523 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AUSTIN, CHRISTINE · 2018 to 2020
$695k
NCRR NIH HHS P51 RR000169NICHD NIH HHS R00 HD087523NIEHS NIH HHS DP2 ES025453NIEHS NIH HHS R00 ES019597NIH HHS P51 OD011107
6 · The paper itself

Abstract

The regular incremental secretion of enamel and dentine can be interrupted during periods of stress resulting in accentuated growth lines. These accentuated lines, visible under light microscopy, provide a chronology of an individual's stress exposure. Previously, we showed that small biochemical changes along accentuated growth lines detected by Raman spectroscopy, coincided with the timing of medical history events and disruptions of weight trajectory in teeth from captive macaques. Here, we translate those techniques to study biochemical changes related to illness and prolonged medical treatment during early infancy in humans. Chemometric analysis revealed biochemical changes related to known stress-induced changes in circulating phenylalanine as well as other biomolecules. Changes in phenylalanine are also known to affect biomineralization which is reflected in changes in the wavenumbers of hydroxyapatite phosphate bands associated with stress in the crystal lattice. Raman spectroscopy mapping of teeth is an objective, minimally-destructive technique that can aid in the reconstruction of an individual's stress response history and provide important information on the mixture of circulating biochemicals associated with medical conditions, as applied in epidemiological and clinical samples.

Indexed as

ToothHumansMicroscopySpectrum Analysis, RamanAccentuated lineRaman spectroscopyStressTeeth

Identifiers

PMID37054846
PMCPMC10167648
OpenAlexW4364355484

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.