Evidence map›Paper›PMID 37054553›Full record

Trial reportPsychiatry research2023

An open label pilot trial of sequential bifrontal low frequency r-TMS in the treatment of primary insomnia.

Richard C Holbert, Brent R Carr, Regina Bussing

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychiatry research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. rTMS in mental health disorders.Frontiers in network physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richard C HolbertDepartment of Psychiatry, University of Florida College of Medicine, 4037 NW 86 Terrace, Gainesville, FL 32606, USA.
Brent R CarrDepartment of Psychiatry, University of Florida, College of Medicine, 4037 NW 86th Terrace, Gainesville, FL, USA.
Regina BussingDepartment of Psychiatry, University of Florida College of Medicine, 4197 NW 86 Terrace, Gainesville, FL 32606, USA. Electronic address: rbussing@ufl.edu.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
NCATS NIH HHS UL1 TR001427
6 · The paper itself

Abstract

This pilot study examines the therapeutic effects of bifrontal low frequency (LF) TMS on primary insomnia. In this prospective, open-label study 20 patients with primary insomnia and without major depressive disorder received 15 sequential bifrontal LF rTMS stimulation sessions. By week 3, PSQI scores declined from baseline score of 12.57(sd 2.74) to 9.50 (sd 4.27), a large effects size (0.80 (CI 0.29, 1.36)), and CGI-I scores improved for 52.6% of participants. Results of this pilot indicate that the novel bifrontal LF rTMS benefitted this group of patients suffering from primary insomnia, with absence of sham control a significant study limitation.

Indexed as

Major Depressive DisorderSleep Initiation and Maintenance DisordersHumansPilot ProjectsPrefrontal CortexProspective StudiesTranscranial Magnetic StimulationTreatment OutcomeLow frequency RTMSOpen label pilot trialPrimary insomnia

Identifiers

PMID37054553
PMCPMC11287436

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.