Observational studyNeurobiology of aging2023
Associations of physical function and body mass index with functional brain networks in community-dwelling older adults.
Observational study in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Evaluation of physical functioning as a marker of brain imaging outcomes in a multiethnic community-based cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Poorer Physical Function Is Associated With Elevated Spatial Entropy in the Aging Brain Network Landscape.Aging cell · 2026Article
- Introducing Structural Reliance: A New Method to Assess Structure-Function Coupling in the Brain.Human brain mapping · 2026Article
- IGROOVE: Protocol for a randomized, controlled, single-blind trial of dance intervention in older adults with subjective cognitive decline.Contemporary clinical trials communications · 2026Article
- The individuality of single-frame functional brain connectivity.bioRxiv : the preprint server for biology · 2026Article
- Contrast Sensitivity Predicts 30-month Functional Brain Network Integrity in Cognitively Unimpaired Older Adults: the Brain Networks and Mobility Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Relationship of Alzheimer's Disease and Related Dementias Plasma Biomarkers With Mobility in Cognitively Unimpaired Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Moderation between resting-state connectivity and brain amyloid levels on speed of cognitive and physical function in older adults: Evidence for network-based cognitive reserve.Aperture neuro · 2025Article
- Age and beta amyloid deposition impact gait speed, stride length, and gait smoothness while transitioning from an even to an uneven walking surface in older adults.Human movement science · 2024Article
- Article
- Amyloid-β Deposition Predicts Grocery Shopping Performance in Older Adults Without Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2024Article
- Differences in Brain Network Topology Based on Alcohol Use History in Adolescents.Brain sciences · 2023Article
- Performance change while learning novel cognitive tasks as a potential identifier of preclinical Alzheimer's disease.Journal of Alzheimer's disease reportsArticle
- The individuality of single-frame functional brain connectivity.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Deficits in physical function that occur with aging contribute to declines in quality of life and increased mortality. There has been a growing interest in examining associations between physical function and neurobiology. Whereas high levels of white matter disease have been found in individuals with mobility impairments in structural brain studies, much less is known about the relationship between physical function and functional brain networks. Even less is known about the association between modifiable risk factors such as body mass index (BMI) and functional brain networks. The current study examined baseline functional brain networks in 192 individuals from the Brain Networks and mobility (B-NET) study, an ongoing longitudinal, observational study in community-dwelling adults aged 70 and older. Physical function and BMI were found to be associated with sensorimotor and dorsal attention network connectivity. There was a synergistic interaction such that high physical function and low BMI were associated with the highest network integrity. White matter disease did not modify these relationships. Future work is needed to understand the causal direction of these relationships.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.