ArticleTissue engineering. Part A2023
Small-Caliber Vascular Grafts Engineered from Decellularized Leaves and Cross-Linked Gelatin.
Article in Tissue engineering. Part A, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Growing Relevance of Decellularized Plant Material as Functional Scaffolds in Tissue Engineering and Cultured Meat: A Scoping Review on Recent Advances, Challenges, and Future Directions.Annals of biomedical engineering · 2026Review
- Plant-Based Scaffolds in Tissue Engineering: Structure-Function, Processing, and Clinical Outlook-A Review.Annals of biomedical engineering · 2026Review
- Implantation of Bioreactor-Conditioned Plant-Based Vascular Grafts.Journal of functional biomaterials · 2026Article
- Autofluorescence Quenching in Decellularized Plant Scaffolds for Tissue Engineering.Annals of biomedical engineering · 2025Article
- Engineering vascular grafts from decellularized plants: Advances and challenges.Histology and histopathology · 2025Review
- Acellular Extracellular Matrix Scaffolds in Regenerative Medicine: Advances in Decellularization and Clinical Applications.Journal of functional biomaterials · 2025Review
- Improving the Biocompatibility of Plant-Derived Scaffolds for Tissue Engineering Using Heat Treatment.Journal of functional biomaterials · 2025Article
- Plant-Based Scaffolds for Tissue Engineering: A Review.Polymers · 2025Review
- Optimization and Standardization of Plant-Derived Vascular Scaffolds.International journal of molecular sciences · 2025Article
- Decellularized Persian walnut leaf (Frontiers in bioengineering and biotechnology · 2025Article
- Biocompatibility of decellularized spinach leaves.npj biomedical innovations · 2025Article
- Perfusion Bioreactor Conditioning of Small-diameter Plant-based Vascular Grafts.Tissue engineering and regenerative medicine · 2024Article
- Human acellular amniotic membrane/polycaprolactone vascular grafts prepared by electrospinning enable vascular remodeling in vivo.Biomedical engineering online · 2024Article
- Decellularized Macroalgae as Complex Hydrophilic Structures for Skin Tissue Engineering and Drug Delivery.Gels (Basel, Switzerland) · 2024Article
- Vascular Damage and Repair - Are Small-Diameter Vascular Grafts Still the "Holy Grail" of Tissue Engineering?Physiological research · 2024Review
- Unconventional strategies for liver tissue engineering: plant, paper, silk and nanomaterial-based scaffolds.Regenerative medicine · 2024Review
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Authors and funding
4 authors.
Funding
Abstract
Despite advances in vascular replacement and repair, fabricating small-diameter vascular grafts with low thrombogenicity and appropriate tissue mechanics remains a challenge. A wide range of platforms have been developed to use plant-derived scaffolds for various applications. Unlike animal tissue, plants are primarily composed of cellulose which can offer a promising, nonthrombogenic alternative capable of promoting cell attachment and redirecting blood flow. By taking advantage of the biocompatibility and mechanical properties of cellulose, we developed small-diameter vascular grafts using decellularized leatherleaf viburnum and cross-linked gelatin. Different terrestrial plant leaves (leatherleaf, spinach, and parsley) were decellularized with sodium dodecyl sulfate, egtazic acid and/or Tergitol, followed by a bleach and Triton X-100 clearing solution, and then evaluated for decellularization efficiency, mechanical integrity, and recellularization potential. Hematoxylin and eosin staining and DNA quantification revealed successful removal of cells in all leatherleaf conditions. Methods of 3D graft fabrication were evaluated, and leatherleaf scaffolds maintained suitable tensile and rupture strength properties. 2D scaffolds and 3D grafts were seeded with rat endothelial cells. Cells remained viable for over 14 days with cell densities comparable to other natural and synthetic scaffolds. This study demonstrates the potential of cost effective and readily available decellularized plants to generate small-diameter vascular grafts capable of recellularization and with suitable mechanical properties. Impact statement Due to the prevalence of coronary heart disease in the United States, small-caliber vascular grafts for coronary bypass surgery are in high demand. We evaluate decellularized plant leaves as potential candidates for small-diameter vascular grafts with appropriate mechanical properties and recellularization potential.
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