Evidence map›Paper›PMID 37053050›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2023

Changes in serum cortisol levels after 10 days of overfeeding and fasting.

Caitlin Colling, Miriam A Bredella, Pouneh K Fazeli, Gisela Pachón-Peña, Ravinder J Singh, Clifford J Rosen, Karen K Miller

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Caitlin CollingNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States.ORCID 0000-0001-9062-8667
Miriam A BredellaHarvard Medical School, Boston, Massachusetts, United States.
Pouneh K FazeliNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States.
Gisela Pachón-PeñaMaine Medical Center Research Institute, Scarborough, Maine, United States.
Ravinder J SinghDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States.
Clifford J RosenMaine Medical Center Research Institute, Scarborough, Maine, United States.
Karen K MillerNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States.
Harvard University · USMaine Medical Center Research Institute · USMayo Clinic · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN K. GRINSPOON · 1994 to 2026
$31.6M
Targeting FSH for the Therapy of Osteoporosis, Obesity and NeurodegenerationU19AG060917 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PENG LIU · 2019 to 2026
$29.0M
TRAINING PROGRAM IN ENDOCRINOLOGY AND DIABETEST32DK007028 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Karen K Miller · 1986 to 2026
$18.5M
Growth Hormone and Cardiovascular DiseaseK24HL092902 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KAREN K · 2010 to 2019
$1.6M
Bone Metabolism in Adolescents UndergoingBariatric SurgeryK24DK109940 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BREDELLA, MIRIAM ANTOINETTE · 2017 to 2021
$970k
Interdisciplinary study of marrow adiposity, mineral metabolism,and energy balancR24DK084970 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, KLIBANSKI, ANNE · 2010 to 2010
$501k
NCATS NIH HHS UL1 TR002541NHLBI NIH HHS K24 HL092902NIA NIH HHS U19 AG060917NIDDK NIH HHS K24 DK109940NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R24 DK084970NIDDK NIH HHS T32 DK007028
6 · The paper itself

Abstract

Chronic caloric deprivation and obesity are complicated by hypercortisolemia. The effects of acute overfeeding and fasting on circulating free cortisol levels and conversion of cortisone to free cortisol are unknown. We hypothesized that serum-free cortisol and free cortisol-to-cortisone ratio would increase after both overfeeding and fasting. This is a prospective study of 22 healthy volunteers who completed a 10-day high-calorie protocol followed by a 10-day fast, separated by a 2-wk washout. Morning free and total cortisol and free cortisone levels (LC/MS) were measured at baseline and after 10 days of each intervention. Both high-calorie feeding and fasting increased total and free cortisol and the free cortisol-to-free cortisone ratio (

Indexed as

CortisoneHydrocortisoneFastingFemaleHumansMaleObesityProspective StudiesCortisoneHydrocortisonefastingfree cortisoloverfeedingstress

Identifiers

PMID37053050
PMCPMC10228666
OpenAlexW4365443770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.