Evidence map›Paper›PMID 37052748›Full record

ArticleJournal of neuro-oncology2023

Clinicopathologic analysis of pineal parenchymal tumors of intermediate differentiation: a multi-institutional cohort study by the Kyushu Neuro-Oncology Study Group.

Shinji Yamashita, Hideo Takeshima, Nobuhiro Hata, Hiroyuki Uchida, Naoki Shinojima, Kiyotaka Yokogami, Yoshiteru Nakano, Kiyohiko Sakata, Hirotaka Fudaba, Toshiyuki Enomoto and 20 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Histopathology and Molecular Pathology of Pineal Region Tumors.Advances and technical standards in neurosurgery · 2026
    Review
  3. Imaging of Pineal Region Masses.Advances and technical standards in neurosurgery · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 11 institutions in 1 country.

Shinji YamashitaDivision of Neurosurgery, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. shinjy@med.miyazaki-u.ac.jp.
Hideo TakeshimaDivision of Neurosurgery, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Nobuhiro HataDepartment of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.
Hiroyuki UchidaDepartment of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Naoki ShinojimaDepartment of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Kiyotaka YokogamiDivision of Neurosurgery, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Yoshiteru NakanoDepartment of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kiyohiko SakataDepartment of Neurosurgery, Kurume University School of Medicine, Kurume, Japan.
Hirotaka FudabaDepartment of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.
Toshiyuki EnomotoDepartment of Neurosurgery, Fukuoka University School of Medicine, Fukuoka, Japan.
Yukiko NakaharaDepartment of Neurosurgery, Faculty of Medicine, Saga University, Saga, Japan.
Kenta UjifukuDepartment of Neurosurgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Kenichi SugawaraDepartment of Neurosurgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Tooru IwakiDepartment of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan.
Yuhei SangatsudaDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Koji YoshimotoDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ryousuke HanayaDepartment of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Akitake MukasaDepartment of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Kohei SuzukiDepartment of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Junkoh YamamotoDepartment of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Tetsuya NegotoDepartment of Neurosurgery, Kurume University School of Medicine, Kurume, Japan.
Hideo NakamuraDepartment of Neurosurgery, Kurume University School of Medicine, Kurume, Japan.
Yasutomo MomiiDepartment of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.
Minoru FujikiDepartment of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.
Hiroshi AbeDepartment of Neurosurgery, Fukuoka University School of Medicine, Fukuoka, Japan.
Jun MasuokaDepartment of Neurosurgery, Faculty of Medicine, Saga University, Saga, Japan.
Tatsuya AbeDepartment of Neurosurgery, Faculty of Medicine, Saga University, Saga, Japan.
Takayuki MatsuoDepartment of Neurosurgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Shogo IshiuchiDepartment of Neurosurgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Kyushu Neuro-Oncology Study Group
Oita University · JPKurume University · JPSaga University · JPUniversity of Miyazaki · JPUniversity of Occupational and Environmental Health Japan · JPFukuoka University · JPKagoshima University · JPKumamoto University · JPKyushu University · JPNagasaki University · JPUniversity of the Ryukyus · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePineal parenchymal tumors of intermediate differentiation (PPTIDs), which were recognized in the 2007 World Health Organization (WHO) classification, are rare, accounting for less than 1% of all central nervous system tumors. This rarity and novelty complicate the diagnosis and treatments of PPTID. We therefore aimed to evaluate the clinicopathological significance of this tumor.

methodsAt 11 institutions participating in the Kyushu Neuro-Oncology Study Group, data for patients diagnosed with PPTID were collected. Central pathology review and KBTBD4 mutation analysis were applied to attain the diagnostically accurate cohort.

resultsPPTID was officially diagnosed in 28 patients: 11 (39%) with WHO grade 2 and 17 (61%) with WHO grade 3 tumors. Median age was 49 years, and the male:female ratio was 1:2.1. Surgery was attempted in all 28 patients, and gross total resection (GTR) was achieved in 46% (13/28). Adjuvant radiotherapy and chemotherapy were administered to, respectively, 82% (23/28) and 46% (13/28). The 5-year progression-free survival (PFS) and overall survival rates were 64.9% and 70.4% respectively. Female sex (p = 0.018) and GTR (p < 0.01) were found to be independent prognostic factors for PFS and female sex (p = 0.019) was that for OS. Initial and second recurrences were most often leptomeningeal (67% and 100% respectively). 80% (20/25) of patients harbored a KBTBD4 mutation.

conclusionsFemale sex and GTR were independent prognostic factors in our patients with PPTID. Leptomeningeal recurrence was observed to be particularly characteristic of this tumor. The rate of KBTBD4 mutation observed in our cohort was acceptable and this could prove the accuracy of our PPTID cohort.

Indexed as

Brain NeoplasmsPineal GlandPinealomaCohort StudiesFemaleHumansMaleMiddle AgedProgression-Free SurvivalRetrospective StudiesCohort studyKBTBD4 mutationLeptomeningeal recurrencePPTID

Identifiers

PMID37052748
OpenAlexW4365443471

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.