Evidence map›Paper›PMID 37052265›Full record

ArticleOncology reports2023

MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression.

Rhafaela Lima Causin, André Van Helvoort Lengert, Izabela Natalia Faria Gomes, Ana Julia Aguiar De Freitas, Marcela Nunes Rosa, Ricardo Dos Reis, Rui Manuel Reis, Márcia Maria Chiquitelli Marques

Open access · hybridAbstract read
In one paragraph

Article in Oncology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rhafaela Lima CausinMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, São Paulo 14784‑400, Brazil.
André Van Helvoort LengertMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, São Paulo 14784‑400, Brazil.
Izabela Natalia Faria GomesMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, São Paulo 14784‑400, Brazil.
Ana Julia Aguiar De FreitasMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, São Paulo 14784‑400, Brazil.
Marcela Nunes RosaMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, São Paulo 14784‑400, Brazil.
Ricardo Dos ReisDepartment of Gynecological Oncology, Barretos Cancer Hospital, Barretos, São Paulo 14784‑400, Brazil.
Rui Manuel ReisMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, São Paulo 14784‑400, Brazil.
Márcia Maria Chiquitelli MarquesMolecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, São Paulo 14784‑400, Brazil.
Hospital de Câncer de Barretos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs or miRs) play essential roles in the initiation and progression of human tumors, including cervical cancer. However, the mechanisms underlying their actions in cervical cancer remain unclear. The present study aimed to evaluate the functional role of miR‑130a‑3p in cervical cancer. Cervical cancer cells were transfected with a miRNA inhibitor (anti‑miR‑130a‑3p) and a negative control. Adhesion‑independent cell proliferation, migration and invasion were evaluated. The findings presented herein demonstrated that miR‑130a‑3p was overexpressed in HeLa, SiHa, CaSki, C‑4I and HCB‑514 cervical cancer cells. The inhibition of miR‑130a‑3p significantly reduced the proliferation, migration and invasion of cervical cancer cells. The canonical delta‑like Notch1 ligand (

Indexed as

MicroRNAsUterine Cervical NeoplasmsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHeLa CellsHumansNeoplasm InvasivenessMicroRNAsbiomarkercervical cancermicroRNA‑130a‑3ptumor progression

Identifiers

PMID37052265
PMCPMC10152451
OpenAlexW4365443724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.