Evidence map›Paper›PMID 37051746›Full record

ArticlePediatric blood & cancer2023

Parental perspective on the risk of infertility and fertility preservation options for children and adolescents with sickle cell disease considering hematopoietic stem cell transplantation.

Cynthia B Sinha, Lillian R Meacham, Nitya Bakshi, Diana Ross, Lakshmanan Krishnamurti

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Cynthia B SinhaDepartment of Pediatric Hematology-Oncology-BMT, Emory University, Atlanta, Georgia, USA.
Lillian R MeachamDepartment of Pediatric Hematology-Oncology-BMT, Emory University, Atlanta, Georgia, USA.
Nitya BakshiDepartment of Pediatric Hematology-Oncology-BMT, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-0876-9506
Diana RossDepartment of Pediatric Hematology-Oncology-BMT, Emory University, Atlanta, Georgia, USA.
Lakshmanan KrishnamurtiYale Pediatric Hematology & Oncology, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-3242-0037
Emory University · USYale Cancer Center · US

Funding

Hematopoietic Stem Cell Transplantation for Young Adults with Sickle Cell Disease - Clinical Coordinating CenterU01HL128566 · NHLBI · YALE UNIVERSITY · PI KRISHNAMURTI, LAKSHMANAN, WALTERS, MARK C · 2015 to 2019
$7.3M
STUDYING INTRA-INDIVIDUAL PAIN VARIABILITY IN SICKLE CELL DISEASE AND RESOLUTION OF PAIN AFTER HEMATOPOIETIC CELL TRANSPLANT: A NOVEL MODEL SYSTEM TO ELUCIDATE MECHANISMS OF TRANSITION TO CHRONIC PAINK23HL140142 · NHLBI · YALE UNIVERSITY · PI BAKSHI, NITYA · 2018 to 2022
$899k
Sickle Cell post Transplantation Long Term and Late Effects Registry ( STELLAR)OT2HL152762 · NHLBI · EMORY UNIVERSITY · PI KRISHNAMURTI, LAKSHMANAN · 2019 to 2019
$750k
NHLBI NIH HHS K23 HL140142NHLBI NIH HHS OT2 HL152762NHLBI NIH HHS U01 HL128566
6 · The paper itself

Abstract

backgroundAllogeneic hematopoietic stem cell transplantation (HCT) performed in children from human leukocyte antigen (HLA)-identical related donors is associated with very high survival rates and disease-free survival. Patients are exposed to gonadotoxic alkylating agents or irradiation in the HCT conditioning regimen. Consequently, infertility is a major long-term complication of HCT for sickle cell disease (SCD). We sought to understand how caregivers perceive the risk of infertility from HCT, how they perceive the options for fertility preservation, and how this risk perception impacted their decision-making to pursue HCT. PROCEDURES: We conducted qualitative interviews with primary caregivers after a consultation for HCT for SCD. Data were analyzed using descriptive qualitative analysis.

resultsWe interviewed 19 primary caregivers who had attended a consultation with an HCT physician (female, age 25-59 [median 39] years). Eleven participants reported that their child had an available HLA-matched donor. Analysis revealed that (i) mothers were worried about death and graft-versus-host disease from HCT, more than about the risk of infertility; (ii) parents have a realistic understanding of the risk of infertility after HCT and take it into consideration in decision-making; (iii) parents report multiple barriers to fertility preservation.

conclusionFor parents actively considering HCT for their child with SCD, the risk of infertility while important was not a barrier to pursuing HCT. Inconvenience and invasiveness of fertility preservation procedures are some of the barriers to pursuing fertility preservation for their child. Future research must aim at addressing these barriers to fertility preservation.

Indexed as

Anemia, Sickle CellFertility PreservationGraft vs Host DiseaseHematopoietic Stem Cell TransplantationInfertilityAdolescentAdultChildFemaleHumansMiddle AgedParentsTransplantation Conditioningfertility preservationgene therapyhematologyhematopoietic stem cell transplantationmedical decision-makingpediatricrisk of infertilitysickle cell disease

Identifiers

PMID37051746
PMCPMC10544372
OpenAlexW4365443433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.