Evidence map›Paper›PMID 37051677›Full record

ArticleThe International journal of artificial organs2023

Oxygenation performance assessment of an artificial lung in different central anatomic configurations.

Flutura Hima, Sebastian Kalverkamp, Ali Kashefi, Khosrow Mottaghy, Rachad Zayat, Lasse Strudthoff, Jan Spillner, Foivos Mouzakis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The International journal of artificial organs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Biomimetic erythrocyte-based drug delivery systems for organ-targeted therapy.Frontiers in bioengineering and biotechnology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Flutura HimaClinic for Thoracic Surgery, University Hospital RWTH Aachen, Aachen, Germany.ORCID 0000-0002-5088-0355
Sebastian KalverkampClinic for Thoracic Surgery, University Hospital RWTH Aachen, Aachen, Germany.
Ali KashefiInstitute of Physiology, RWTH Aachen University, Aachen, Germany.
Khosrow MottaghyInstitute of Physiology, RWTH Aachen University, Aachen, Germany.
Rachad ZayatClinic for Thoracic Surgery, University Hospital RWTH Aachen, Aachen, Germany.
Lasse StrudthoffDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, Germany.
Jan SpillnerClinic for Thoracic Surgery, University Hospital RWTH Aachen, Aachen, Germany.
Foivos MouzakisInstitute of Physiology, RWTH Aachen University, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAim of this work was to characterize possible central anatomical configurations in which a future artificial lung (AL) could be connected, in terms of oxygenation performance.

methodsPulmonary and systemic circulations were simulated using a numerical and an in vitro approach. The in vitro simulation was carried out in a mock loop in three phases: (1) normal lung, (2) pulmonary shunt (50% and 100%), and (3) oxygenator support in three anatomical configurations: right atrium-pulmonary artery (RA-PA), pulmonary artery-left atrium (PA-LA), and aorta-left atrium (Ao-LA). The numerical simulation was performed for the oxygenator support phase. The oxygen saturation (SO

resultsDuring the pulmonary shunt phase, SO

conclusionsBoth in vitro and numerical simulations were able to properly characterize oxygenation properties of a future AL depending on its placement. Different anatomical configurations perform differently in terms of oxygenation. Right to right and right to left connections perform better than left to left ones.

Indexed as

LungPulmonary ArteryHeart AtriaOxygenOxygenatorsVentilators, MechanicalOxygenartificial lung and respiratory supportcentral anatomic configurationGas exchangemock loopnumerical simulation

Identifiers

PMID37051677
PMCPMC10160396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.