ArticleRenal failure2023
Thyroid function analysis after roxadustat or erythropoietin treatment in patients with renal anemia: a cohort study.
Article in Renal failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Effects of hypoxia-inducible factor prolyl hydroxylase inhibitors on lipid profiles in patients with chronic kidney disease: a systematic review and meta-analysis.European journal of clinical pharmacology · 2026Pooled it
- Initial side effects of roxadustat on thyroid function in patients undergoing hemodialysis.Renal failure · 2026Article
- Roxadustat Activates Thyroid Hormone Receptors α and β at Clinically Relevant Concentrations.Cureus · 2025Article
- Linking thyroid dysfunction with chronic kidney disease among Indian patients.Bioinformation · 2025Article
- Roxadustat has risks of reversible central hypothyroidism in patients undergoing hemodialysis: a single-center retrospective cohort study.Renal failure · 2024Article
- Cerebral Infarction After Switching From Roxadustat to Daprodustat in a Patient With Renal Anemia.Cureus · 2024Article
- Association between roxadustat use and suppression of thyroid function: a systematic review and meta-analysis.Journal of pharmaceutical health care and sciences · 2024Article
- Effects of roxadustat on thyroid hormone levels and blood lipid metabolism in patients undergoing hemodialysis: a retrospective study.International journal of medical sciences · 2024Article
- Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors and Hypothyroidism: An Analysis of the Japanese Pharmacovigilance Database.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis cohort study was designed to explore whether roxadustat or erythropoietin could affect thyroid function in patients with renal anemia.
methodsThe study involved 110 patients with renal anemia. Thyroid profile and baseline investigations were carried out for each patient. The patients were divided into two groups: 60 patients taking erythropoietin served as the control group (rHuEPO group) and 50 patients using roxadustat served as the experimental group (roxadustat group).
resultsThe results indicated that there were no significant differences in serum total thyroxine (TT4), total triiodothyronine (TT3), free triiodothyronine (FT3), free thyroxine (FT4) or thyroid stimulating hormone (TSH) between the two groups at baseline. After treatment, TSH, FT3, and FT4 were significantly lower in the roxadustat group than in the rHuEPO group (
conclusionRoxadustat may lead to a higher risk of thyroid dysfunction, including low TSH, FT3 and FT4, than rHuEPO in patients with renal anemia.
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