ArticleFrontiers in nutrition2023
Structural characterization and anti-inflammatory activity of a novel polysaccharide PKP2-1 from
Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
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- Unlocking the in vitro and in vivo antioxidant and anti-inflammatory activities of polysaccharide fractions fromHeliyon · 2024Article
- Structural Characterization of Polygonatum Cyrtonema Polysaccharide and Its Immunomodulatory Effects on Macrophages.Molecules (Basel, Switzerland) · 2024Article
- In Vivo Pharmacokinetic Study ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides fromMolecules (Basel, Switzerland) · 2023Review
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Introduction: This study aimed to investigate the structure characterization and antiinflammatory activity of a novel polysaccharide, PKP2-1, from the rhizomes of Methods: We isolated a novel polysaccharide, PKP2-1, from the rhizomes of Results: Monosaccharide composition assay revealed that PKP2-1 was mainly composed of glucose, galactose, mannose, and glucuronic acid at an approximate molar ratio of 6:2:2:1. It had a molecular weight of approximately 17.34 kDa. Structural investigation revealed that the backbone of PKP2-1 consisted of (→2, 3)-α-D-Galp(4→, →2)-α-D-Manp(3→, →2)-β-D-Glcp(4→) and α-D-Glcp(3→) residues with side chains (→2)-β-D-Glcp(4→, →1)-α-D-Galp(4→) and α-D-Glcp(3→) branches located at O-3 position of (→2, 3)-α-D-Galp(4→). The Conclusion: The PKP2-1 could inhibit MH7A cell growth and potentially be exploited as an anti-inflammatory agent.
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