ReviewPolymers2023
Mechanism of Heterogeneous Alkaline Deacetylation of Chitin: A Review.
Review in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 81 citations in OpenAlex.
- Fungal Biotechnology for Sustainable Biocomposites: From Mycelium Growth to Material Translation.Molecules (Basel, Switzerland) · 2026Review
- Chitosan-Based Hydrogels in Vascular Tissue Engineering Applications.Materials (Basel, Switzerland) · 2026Review
- A comparative study on heterogeneous deacetylation of chitin to chitosan under various ultrasound irradiation and characterization.Ultrasonics sonochemistry · 2026Article
- Colloidal Deacetylation of Chitin Nanocrystals Results in Amorphous and Patchy Chitosan Chains.ACS nano · 2026Article
- Beyond Averages: Chitosan Dispersity Affects the Bioactivity Reproducibility on In Vitro Maize (var.Polymers · 2026Article
- Chitosan Derivatives: Challenges and Opportunities in the Green and Sustainable Transition Era.Molecules (Basel, Switzerland) · 2026Review
- Recent Applications of Chitosan-Based Biomaterials as Wound Dressings.International journal of molecular sciences · 2026Review
- Article
- Recent advances of MXene/chitosan nanocomposites for industrial applications.Discover nano · 2025Review
- A Nanomicelles Platform Delivery System for Water-Insoluble Corticosteroid to Treat Anterior Uveitis.The AAPS journal · 2025Article
- Effectiveness of Acidic Chitosan Solutions for Total Organic Carbon Removal in Drinking Water Treatment.Polymers · 2025Article
- Article
- Black Soldier Fly Culture as a Source of Chitin and Chitosan for Its Potential Use in Concrete: An Overview.Polymers · 2025Review
- Review
- Heterogeneously deacetylated chitosans possess an unexpected regular pattern favoring acetylation at every third position.Nature communications · 2024Article
- Chitosan and Its Derivatives: Preparation and Antibacterial Properties.Materials (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This review provides an analysis of experimental results on the study of alkaline heterogeneous deacetylation of chitin obtained by the authors and also published in the literature. A detailed analysis of the reaction kinetics was carried out considering the influence of numerous factors: reaction reversibility, crystallinity and porosity of chitin, changes in chitin morphology during washing, alkali concentration, diffusion of hydroxide ions, and hydration of reacting particles. A mechanism for the chitin deacetylation reaction is proposed, taking into account its kinetic features in which the decisive role is assigned to the effects of hydration. It has been shown that the rate of chitin deacetylation increases with a decrease in the degree of hydration of hydroxide ions in a concentrated alkali solution. When the alkali concentration is less than the limit of complete hydration, the reaction practically does not occur. Hypotheses have been put forward to explain the decrease in the rate of the reaction in the second flat portion of the kinetic curve. The first hypothesis is the formation of "free" water, leading to the hydration of chitin molecules and a decrease in the reaction rate. The second hypothesis postulates the formation of a stable amide anion of chitosan, which prevents the nucleophilic attack of the chitin macromolecule by hydroxide ions.
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Registered trials
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