Evidence map›Paper›PMID 37049966›Full record

ArticleMolecules (Basel, Switzerland)2023

1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as Novel Anticancer Agents: Synthesis, Biological Evaluation and Molecular Modeling Insights.

Tarfah Al-Warhi, Hadia Almahli, Raed M Maklad, Zainab M Elsayed, Mahmoud A El Hassab, Ohoud J Alotaibi, Nada Aljaeed, Rezk R Ayyad, Hazem A Ghabour, Wagdy M Eldehna and 1 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tarfah Al-WarhiDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Hadia AlmahliDepartment of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Raed M MakladDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.ORCID 0000-0002-5219-4842
Zainab M ElsayedScientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
Mahmoud A El HassabDepartment of Medicinal Chemistry, Faculty of Pharmacy, King Salman International University (KSIU), South Sinai 46612, Egypt.ORCID 0000-0002-6795-4816
Ohoud J AlotaibiDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Nada AljaeedDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Rezk R AyyadDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.
Hazem A GhabourDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0002-1011-0276
Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.ORCID 0000-0001-6996-4017
Mohamed K El-AshreyPharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr Elini St., Cairo 11562, Egypt.ORCID 0000-0002-3548-3888

Funding

Princess Nourah bint Abdulrahman University (RGP-1440 -0025)(2)
6 · The paper itself

Abstract

Human health is experiencing several obstacles in the modern medical era, particularly cancer. As a result, the cancer therapeutic arsenal should be continually expanded with innovative small molecules that preferentially target tumour cells. In this study, we describe the development of two small molecule series (

Indexed as

Antineoplastic AgentsVascular Endothelial Growth Factor Receptor-2Cell ProliferationDrug Screening Assays, AntitumorHumansMCF-7 CellsMolecular Docking SimulationMolecular StructureProtein Kinase InhibitorsStructure-Activity RelationshipAntineoplastic AgentsProtein Kinase InhibitorsVascular Endothelial Growth Factor Receptor-2A-549 cellsanti-proliferativeisatinMCF-7 cellsmolecular dynamicsthiazoleVEGFR-2 inhibitor

Identifiers

PMID37049966
PMCPMC10096524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.