Anchoring of Polymer Loops on Enzyme-Immobilized Mesoporous ZIF-8 Enhances the Recognition Selectivity of Angiotensin-Converting Enzyme Inhibitory Peptides.

Zefen Wang, Qian Zhou, Siyuan Liu, Dankui Liao, Pengru Liu, Xiongdiao Lan

Open access · goldAbstract read

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Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

0.2field-weighted citation impact, top 43% of its field

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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0 citing papers in PubMed, 1 citations in OpenAlex.

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zefen WangSchool of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.

Qian ZhouSchool of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.

Siyuan LiuGuangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530006, China.

Dankui LiaoSchool of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.

Pengru LiuGuangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530006, China.

Xiongdiao LanGuangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530006, China.

Guangxi University · CNMinzu University of China · CN

Funding

Guangxi Higher Education Institutes Young Teachers Basic Ability Improvement Project 2019KY0170Guangxi Natural Science Foundation 2017GXNSFDA198052Guangxi Natural Science Foundation 2021GXNSFAA075043Guangxi Natural Science Foundation 2022GXNSFBA035499Natural Science Foundation of China 52162004

6 · The paper itself

Abstract

Immobilized angiotensin-converting enzyme (ACE) is a promising material for the rapid screening of antihypertensive drugs, but the nonspecific adsorption is a serious problem in separation processes involving complex biological products. In this study, triblock copolymers with dopamine (DA) block as anchors and PEG block as the main body (DA-PEGx-DA) were attached to an immobilized ACE (ACE@mZIF-8/PDA, AmZP) surface via the "grafting to" strategy which endowed them with anti-nonspecific adsorption. The influence of DA-PEGx-DA chain length on nonspecific adsorption was confirmed. The excellent specificity and reusability of the obtained ACE@mZIF-8/PDA/DA-PEG

Indexed as

Angiotensin-Converting Enzyme InhibitorsPeptidesAngiotensinsAntihypertensive AgentsPeptidyl-Dipeptidase AAngiotensin-Converting Enzyme InhibitorsAngiotensinsAntihypertensive AgentsPeptidesPeptidyl-Dipeptidase Aangiotensin converting enzymeimmobilization of enzymemesoporous ZIF-8polymer loopsrecognition selectivity

Identifiers

PMID37049880

DOI10.3390/molecules28073117

PMCPMC10095817

OpenAlexW4362519944

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.