(Pro)Renin Receptor Decoy Peptide PRO20 Protects against Oxidative Renal Damage Induced by Advanced Oxidation Protein Products.

Hui Fang, Teng Yang, Baolong Zhou, Xinxuan Li

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.7field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Therapeutic potential ofFrontiers in pharmacology · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hui FangSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.ORCID 0000-0002-4795-8238

Teng YangSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.

Baolong ZhouSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.

Xinxuan LiSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.

Weifang Medical University · CN

Funding

National Natural Science Foundation of China 82000400Weifang Science and Technology Development Plan 2021YX043

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is associated with advanced oxidation protein products (AOPPs). A recent study has shown that AOPP-induced renal tubular injury is mediated by the (pro)renin receptor (PRR). However, it is unclear whether the PRR decoy inhibitor PRO20 can protect against renal damage related to AOPPs in vivo. In this study, we examined the role of the PRR in rats with AOPP-induced renal oxidative damage. Male SD rats were subjected to unilateral nephrectomy, and after a four-day recuperation period, they were randomly divided into four groups (

Indexed as

Advanced Oxidation Protein ProductsRenal Insufficiency, ChronicAnimalsHydrogen PeroxideKidneyMaleOxidative StressPeptidesProrenin ReceptorRatsRats, Sprague-DawleyAdvanced Oxidation Protein ProductsHydrogen PeroxidePeptidesProrenin Receptoradvanced oxidation protein productschronic kidney diseasePRO20(pro)renin receptorrenin-angiotensin system

Identifiers

PMID37049779

DOI10.3390/molecules28073017

PMCPMC10096258

OpenAlexW4361221437

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.