Evidence map›Paper›PMID 37049602›Full record

ReviewNutrients2023

Can Circadian Eating Pattern Adjustments Reduce Risk or Prevent Development of T2D?

Carlee Harris, Krzysztof Czaja

Abstract readReview
In one paragraph

Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. The CommonNutrients · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Circadian nutrition and obesity: timing as a nutritional strategy.Journal of health, population, and nutrition · 2025
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Carlee HarrisDepartment of Biomedical Sciences, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Krzysztof CzajaDepartment of Biomedical Sciences, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-7165-4218

Funding

Vagal Influence on Brainstem Plasticity and Neural Coding of TasteR01DC013904 · NIDCD · UNIVERSITY OF GEORGIA · PI CZAJA, KRZYSZTOF, DI LORENZO, PATRICIA M · 2015 to 2018
$2.5M
NIH HHS 5R01DC013904
6 · The paper itself

Abstract

Type 2 diabetes (T2D) is a chronic condition that occurs in insulin-resistant people with reduced glucose uptake. It is contributed to and exacerbated by a poor diet that results in accumulation of adipose tissue, high blood sugar, and other metabolic issues. Because humans have undergone food scarcity throughout history, our species has adapted a fat reserve genotype. This adaptation is no longer beneficial, as eating at a higher frequency than that of our ancestors has had a significant effect on T2D development. Eating at high frequencies disrupts the circadian clock, the circadian rhythm, and the composition of the gut microbiome, as well as hormone secretion and sensitivity. The current literature suggests an improved diet requires meal consistency, avoiding late-night eating, low meal frequency, and fasting to increase metabolic health. In addition, fasting as a treatment for T2D must be used correctly for beneficial results. Early time-restricted eating (TRE) provides many benefits such as improving insulin resistance, cognitive function, and glycemic control. Alternate-day fasting (ADF), 5:2 fasting, and long-term fasting all have benefits; however, they may be less advantageous than early TRE. Therefore, eating pattern adjustments can be used to reduce T2D if used correctly.

Indexed as

Diabetes Mellitus, Type 2Circadian RhythmEatingFastingFeeding BehaviorHumansInsulinInsulin5:2 fastingalternate-day fastingcircadian rhythmeating patternsintermittent fastinglong-term fastingmetabolic hormonesmicrobiometime-restricted eatingtype 2 diabetes

Identifiers

PMID37049602
PMCPMC10096926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.