Evidence map›Paper›PMID 37049599›Full record

ReviewNutrients2023

Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours.

Neeraj K Singh, Jeffrey M Beckett, Krishnakumar Kalpurath, Muhammad Ishaq, Tauseef Ahmad, Rajaraman D Eri

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Immune-microbiota crosstalk in colorectal cancer: mechanistic pathways, biomarkers, and translational therapeutics.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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  8. Review
  9. Review
  10. Review
  11. Article
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  13. Article
  14. Therapeutic Effect ofDrug design, development and therapy · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Neeraj K SinghSchool of Health Sciences, University of Tasmania, Newnham, Launceston 7248, Australia.
Jeffrey M BeckettSchool of Health Sciences, University of Tasmania, Newnham, Launceston 7248, Australia.ORCID 0000-0002-2911-0313
Krishnakumar KalpurathSchool of Health Sciences, University of Tasmania, Newnham, Launceston 7248, Australia.
Muhammad IshaqSchool of Health Sciences, University of Tasmania, Newnham, Launceston 7248, Australia.ORCID 0000-0002-4498-7930
Tauseef AhmadSchool of Health Sciences, University of Tasmania, Newnham, Launceston 7248, Australia.ORCID 0000-0001-5322-9413
Rajaraman D EriSchool of Health Sciences, University of Tasmania, Newnham, Launceston 7248, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy is still the first line of treatment for most cancer patients. Patients receiving chemotherapy are generally prone to infections, which result in complications, such as sepsis, mucositis, colitis, and diarrhoea. Several nutritional approaches have been trialled to counter the chemotherapy-associated side effects in cancer patients, but none have yet been approved for routine clinical use. One of the approaches to reduce or avoid chemotherapy-associated complications is to restore the gut microbiota. Gut microbiota is essential for the healthy functioning of the immune system, metabolism, and the regulation of other molecular responses in the body. Chemotherapy erodes the mucosal layer of the gastrointestinal tract and results in the loss of gut microbiota. One of the ways to restore the gut microbiota is through the use of probiotics. Probiotics are the 'good' bacteria that may provide health benefits if consumed in appropriate amounts. Some studies have highlighted that the consumption of probiotics in combination with prebiotics, known as synbiotics, may provide better health benefits when compared to probiotics alone. This review discusses the different nutritional approaches that have been studied in an attempt to combat chemotherapy-associated side effects in cancer patients with a particular focus on the use of pre-, pro- and synbiotics.

Indexed as

NeoplasmsProbioticsSynbioticsGastrointestinal TractHumansPrebioticsPrebioticscancerchemotherapyprebioticsprobioticssynbiotics

Identifiers

PMID37049599
PMCPMC10096799

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.