Evidence map›Paper›PMID 37049591›Full record

ArticleNutrients2023

Dysbiosis of the Gut Microbiota and Kynurenine (Kyn) Pathway Activity as Potential Biomarkers in Patients with Major Depressive Disorder.

Ping Lin, Dan Li, Yun Shi, Qingtian Li, Xiaokui Guo, Ke Dong, Qing Chen, Xiaoyan Lou, Zhenhua Li, Ping Li and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Ping LinDepartment of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Dan LiDepartment of Clinical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Yun ShiDepartment of Clinical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Qingtian LiDepartment of Microbiology and Immunology, The College of Basic Medical Science, Shanghai Jiao Tong University, Shanghai 200025, China.ORCID 0000-0003-1170-0806
Xiaokui GuoDepartment of Microbiology and Immunology, The College of Basic Medical Science, Shanghai Jiao Tong University, Shanghai 200025, China.
Ke DongDepartment of Microbiology and Immunology, The College of Basic Medical Science, Shanghai Jiao Tong University, Shanghai 200025, China.ORCID 0000-0003-2868-8452
Qing ChenDepartment of Clinical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Xiaoyan LouDepartment of Clinical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Zhenhua LiDepartment of Clinical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Ping LiDepartment of Clinical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Weifeng JinDepartment of Clinical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Shuzi ChenDepartment of Clinical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Yang SunInstitute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai 200052, China.
Jing SunInstitute for Integrated Intelligence and Systems, School of Medicine and Dentistry, Griffith University, Gold Coast Campus, Gold Coast, QLD 4215, Australia.ORCID 0000-0002-0097-2438
Xunjia ChengDepartment of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0000-0002-8851-6903
Shanghai Jiao Tong University · CNShanghai Medical College of Fudan University · CNUniversity of Technology Sydney · AU

Funding

China Public Health Union (First) Project GWLM202014Shanghai Mental Health Center 2017-TSXK-07Shanghai Municipal Commission of Health and Family Planning 2018LP024Shanghai Natural Science fund Project 20ZR1447700The hospital-level project of Shanghai Mental Health Center 020-YJ05
6 · The paper itself

Abstract

With increasing attention paid to the concept of the microbiota-gut-brain axis, mounting evidence reveals that the gut microbiota is involved in a variety of neurological and psychiatric diseases. However, gut microbiota changes in major depressive disorder (MDD) patients and their association with disease mechanisms remain undefined. Fifty MDD patients and sixty healthy controls were recruited from the Shanghai Healthy Mental Center, China. Fecal samples were collected, and the compositional characteristics of the intestinal flora were determined in MDD patients by MiSeq sequencing. Venous blood was collected for the detection of plasma indoleamine-2,3-dioxygenase (Ido), kynurenine (Kyn) and tryptophan (Trp) levels. Stool samples of bacterial 16S sequencing was carried out. A total of 2,705,809 optimized sequences were obtained, with an average of 54,116 per sample. More unique OTUs were observed at the family, genus and species levels in the control group compared with the MDD cases. Further analysis showed significant changes in the α- and β-diversities and relative abundance levels of gut microbial entities in MDD patients, as well as elevated amounts of Ido and Kyn indicating Kyn pathway activation, KEGG bacterial 16S function prediction analysis shows a variety of amino acids and metabolic (including Ido, Trp and Kyn) changes in the body of patients with MDD. These may result in increased neurotoxic metabolites and reduced generation of serotonin in the disease process. These changed factors may potentially be utilized as biomarkers for MDD in the future, playing more important roles in the disease course.

Indexed as

Gastrointestinal MicrobiomeMajor Depressive DisorderBiomarkersChinaDysbiosisHumansKynurenineTryptophanBiomarkersKynurenineTryptophanbiomarkersgut microbiotakynureninemajor depressive disorder

Identifiers

PMID37049591
PMCPMC10096701
OpenAlexW4362560485

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.