ReviewNutrients2023
Vitamin D and Calcium Supplementation and Urolithiasis: A Controversial and Multifaceted Relationship.
Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Brazilian Guidelines on evaluation and clinical management of Nephrolithiasis: Brazilian Society of Nephrology.Jornal brasileiro de nefrologiaGuideline
- Evidence for nephrolithiasis preceding sarcoidosis diagnosis: findings from a Swedish case-control study.Respiratory research · 2026Article
- Ankylosing spondylitis: an independent risk factor for nephrolithiasis and the prognostic value of follow-up CT.Abdominal radiology (New York) · 2026Article
- Osteogenic Effects ofFoods (Basel, Switzerland) · 2026Article
- The effect of geography and climatic factors on the hospitality burden due to kidney stones in Spain 1997-2022.Open research Europe · 2026Article
- Lifestyle and Environment Aspects Challenging Kidney Health.Kidney & blood pressure research · 2026Review
- Article
- Genetically predicted blood metabolites mediate the association between immune cell characteristics and urolithiasis: A Mendelian randomization study and mediation analysis.Genes & diseases · 2025Article
- Dysregulated lipid metabolism in kidney stone pathogenesis: a literature review of mechanistic insights and therapeutic implications.BMC urology · 2025Review
- [Association of serum vitamin D and acute renal graft dysfunction].Revista medica del Instituto Mexicano del Seguro Social · 2025Observational
- Uncovering the subtle relationship between vitamin D and kidney stones: a cross-sectional NHANES-based study.European journal of medical research · 2025Article
- Article
- Research trends and frontiers on risk factors of urinary stones: a bibliometric analysis from 2010 to 2023.Renal failure · 2024Article
- The essential role of combined calcium and vitamin D supplementation in the osteoporosis scenario in italy: Expert opinion paper.Archives of osteoporosis · 2024Review
- Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study.International urology and nephrology · 2024Article
- The complex relationship between vitamin D and kidney stones: balance, risks, and prevention strategies.Frontiers in nutrition · 2024Review
- Association between milk consumption and kidney stones in U.S. adults: results from NHANES 2007-2018.Frontiers in nutrition · 2024Article
- Unlocking New Approaches to Urolithiasis ManagementCurrent pharmaceutical biotechnology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with urolithiasis, and particularly those with hypercalciuria, frequently have a marked reduction of bone mineral content up to the levels of osteoporosis, with a significant increase in bone fracture risk. For these reasons, the indication to prescribe vitamin D and/or calcium supplementations is very frequent in such patients. On the other hand, both calcium supplementation, and even more vitamin D therapy, can worsen the risk of developing urolithiasis by increasing calcium, phosphate, and oxalate urinary excretion. Despite the clinical and practical relevance of this issue, the evidence on this topic is scarce and contradictory. Therefore, some concerns exist about how and whether to prescribe such supplements to a patient with a history of kidney stones. In this narrative review, we resume some pivotal pathophysiological concepts strictly related to the dealt topic, and we draw some considerations and personal opinions on the pros and cons of such prescriptions. Finally, we share with the reader our pragmatic algorithm for handling the urolithiasis risk in patients who have strong indications to be prescribed vitamin D and calcium supplementations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.