Trial reportNutrients2023
Psychobiotic Effects on Anxiety Are Modulated by Lifestyle Behaviors: A Randomized Placebo-Controlled Trial on Healthy Adults.
Trial report in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04823533 (A Psychophysiological Study of the Bidirectional Communication Mechanisms Between the Brain and the Gastrointestinal System and Its Effects on Well-being), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Psychophysiological Study of the Bidirectional Communication Mechanisms Between the Brain and the Gastrointestinal System and Its Effects on Well-being
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Probiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.BMC psychology · 2026Pooled it
- The effects of oral probiotic intervention on brain structure and function in human adults: a systematic review.NPJ biofilms and microbiomes · 2026Pooled it
- Can We Modulate Our Second Brain and Its Metabolites to Change Our Mood? A Systematic Review on Efficacy, Mechanisms, and Future Directions of "Psychobiotics".International journal of molecular sciences · 2025Pooled it
- The effects of pyrroloquinoline quinone and nicotinamide mononucleotide supplementation on interoception following acute exhaustive exercise: a randomised, double-blind, placebo-controlled study.Scientific reports · 2026Trial
- Metabolic Status Influences Probiotic Efficacy for Depression-PRO-DEMET Randomized Clinical Trial Results.Nutrients · 2024Trial
- From Gut to Mind: Impact of Probiotics on Depression, Anxiety, Mood, Gut Microbiota, Sleep and Stress-A Systematic Review of RCTs.Annals of neurosciences · 2026Review
- Gut-Brain-Skin Axis: From Mechanistic Insights to Translational Applications in Neurocosmetics.Dermatology and therapy · 2026Review
- Unraveling the gut microbiota-brain axis: Mechanisms, pathophysiology, and therapeutic opportunities.iScience · 2026Review
- Probiotics as Modulators of Adult Neurogenesis and Synaptic Plasticity: New Perspectives in the Pathophysiology and Treatment of Affective Disorders.Biomedicines · 2026Review
- Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis.Frontiers in microbiology · 2026Review
- Evaluating the scientific evidence to support mental health and well-being claims made on probiotic products.Nutrition and health · 2025Review
- Psychobiotics at the Frontiers of Neurodegenerative and Neuropsychiatric Research.Microorganisms · 2025Review
- The psychobiotic revolution: comprehending the optimistic role of gut microbiota on gut-brain axis during neurological and Gastrointestinal (GI) disorders.World journal of microbiology & biotechnology · 2025Review
- Efficacy ofInternational journal of molecular sciences · 2025Article
- Sustainable Innovations in Food Microbiology: Fermentation, Biocontrol, and Functional Foods.Foods (Basel, Switzerland) · 2025Review
- Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms.Journal of personalized medicine · 2025Review
- Probiotic supplementation for optimizing athletic performance: current evidence and future perspectives for microbiome-based strategies.Frontiers in nutrition · 2025Review
- Precision Psychobiotics for Gut-Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy.Microbial biotechnology · 2025Review
- The Relationship Between Mental Health Literacy and Social Well-Being: A Longitudinal Study in China.Behavioral sciences (Basel, Switzerland) · 2024Article
- Low mental health literacy is associated with depression and anxiety among adults: a population-based survey of 16,715 adults in China.BMC public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Psychobiotics are modulators of the Microbiota-Gut-Brain Axis (MGBA) with promising benefits to mental health. Lifestyle behaviors are established modulators of both mental health and the MGBA. This randomized placebo-controlled clinical trial (NCT04823533) on healthy adults (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.