Evidence map›Paper›PMID 37049431›Full record

ArticleNutrients2023

Circulating Metabolomic and Lipidomic Signatures Identify a Type 2 Diabetes Risk Profile in Low-Birth-Weight Men with Non-Alcoholic Fatty Liver Disease.

Line O Elingaard-Larsen, Sofie O Villumsen, Louise Justesen, Anne Cathrine B Thuesen, Min Kim, Mina Ali, Else R Danielsen, Cristina Legido-Quigley, Gerrit van Hall, Torben Hansen and 3 more

Abstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Line O Elingaard-LarsenSteno Diabetes Center Copenhagen, 2730 Herlev, Denmark.
Sofie O VillumsenSteno Diabetes Center Copenhagen, 2730 Herlev, Denmark.ORCID 0000-0002-9096-1555
Louise JustesenSteno Diabetes Center Copenhagen, 2730 Herlev, Denmark.
Anne Cathrine B ThuesenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0002-8639-9117
Min KimSteno Diabetes Center Copenhagen, 2730 Herlev, Denmark.
Mina AliSteno Diabetes Center Copenhagen, 2730 Herlev, Denmark.ORCID 0000-0001-9995-715X
Else R DanielsenDepartment of Radiology, Rigshospitalet, 2100 Copenhagen, Denmark.
Cristina Legido-QuigleySteno Diabetes Center Copenhagen, 2730 Herlev, Denmark.
Gerrit van HallClinical Metabolomics Core Facility, Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
Tarunveer S AhluwaliaSteno Diabetes Center Copenhagen, 2730 Herlev, Denmark.ORCID 0000-0002-7464-3354
Allan A VaagSteno Diabetes Center Copenhagen, 2730 Herlev, Denmark.ORCID 0000-0002-3690-2191
Charlotte BrønsSteno Diabetes Center Copenhagen, 2730 Herlev, Denmark.

Funding

Novo Nordisk Foundation NNF15OC0016692Novo Nordisk Foundation NNF18OC0052457
6 · The paper itself

Abstract

The extent to which increased liver fat content influences differences in circulating metabolites and/or lipids between low-birth-weight (LBW) individuals, at increased risk of type 2 diabetes (T2D), and normal-birth-weight (NBW) controls is unknown. The objective of the study was to perform untargeted serum metabolomics and lipidomics analyses in 26 healthy, non-obese early-middle-aged LBW men, including five men with screen-detected and previously unrecognized non-alcoholic fatty liver disease (NAFLD), compared with 22 age- and BMI-matched NBW men (controls). While four metabolites (out of 65) and fifteen lipids (out of 279) differentiated the 26 LBW men from the 22 NBW controls (

Indexed as

Diabetes Mellitus, Type 2Non-alcoholic Fatty Liver DiseaseHumansInfant, Low Birth WeightInfant, NewbornLipidomicsLipidsMaleMiddle AgedLipidslipidomicsliver fatlow-birth-weightmetabolomicsnon-alcoholic fatty liver diseasetype 2 diabetes

Identifiers

PMID37049431
PMCPMC10096690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.