Evidence map›Paper›PMID 37049406›Full record

ArticleNutrients2023

Impact of High Salt-Intake on a Natural Gut Ecosystem in

Alessio Cardilli, Ibrahim Hamad, Aleksandra Dyczko, Sofie Thijs, Jaco Vangronsveld, Dominik N Müller, Stephan P Rosshart, Markus Kleinewietfeld

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Gut Microbiota as a Mediator of Dietary Salt Effects on Blood Pressure.International journal of molecular sciences · 2026
    Review
  2. Gut microbiota-derived polyamine pathways associated with mean blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  3. Article
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  6. Review
  7. Article
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  9. Is fruits granola beneficial for blood pressure management?Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Alessio CardilliVIB Laboratory of Translational Immunomodulation, Center for Inflammation Research (IRC), Hasselt University, 3590 Diepenbeek, Belgium.
Ibrahim HamadVIB Laboratory of Translational Immunomodulation, Center for Inflammation Research (IRC), Hasselt University, 3590 Diepenbeek, Belgium.
Aleksandra DyczkoVIB Laboratory of Translational Immunomodulation, Center for Inflammation Research (IRC), Hasselt University, 3590 Diepenbeek, Belgium.
Sofie ThijsEnvironmental Biology, Centre for Environmental Sciences, Hasselt University, Agoralaan Building D, 3590 Diepenbeek, Belgium.ORCID 0000-0002-2931-9619
Jaco VangronsveldEnvironmental Biology, Centre for Environmental Sciences, Hasselt University, Agoralaan Building D, 3590 Diepenbeek, Belgium.ORCID 0000-0003-4423-8363
Dominik N MüllerExperimental and Clinical Research Center, A Joint Cooperation of Max-Delbrück-Center for Molecular Medicine and Charité-Universitätsmedizin, 13125 Berlin, Germany.
Stephan P RosshartDepartment of Microbiome Research, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen, Germany.ORCID 0000-0002-6989-8686
Markus KleinewietfeldVIB Laboratory of Translational Immunomodulation, Center for Inflammation Research (IRC), Hasselt University, 3590 Diepenbeek, Belgium.ORCID 0000-0002-2832-3149
Hasselt University · BEMaria Curie-Skłodowska University · PLMax Delbrück Center · DEUniversity of Freiburg · DE

Funding

European Research Council 640116
6 · The paper itself

Abstract

The mammalian holobiont harbors a complex and interdependent mutualistic gut bacterial community. Shifts in the composition of this bacterial consortium are known to be a key element in host health, immunity and disease. Among many others, dietary habits are impactful drivers for a potential disruption of the bacteria-host mutualistic interaction. In this context, we previously demonstrated that a high-salt diet (HSD) leads to a dysbiotic condition of murine gut microbiota, characterized by a decrease or depletion of well-known health-promoting gut bacteria. However, due to a controlled and sanitized environment, conventional laboratory mice (CLM) possess a less diverse gut microbiota compared to wild mice, leading to poor translational outcome for gut microbiome studies, since a reduced gut microbiota diversity could fail to depict the complex interdependent networks of the microbiome. Here, we evaluated the HSD effect on gut microbiota in CLM in comparison to

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAnimalsBacillotaBacteriaDietEubacterialesFeeding BehaviorHumansMammalsMiceRNA, Ribosomal, 16SRNA, Ribosomal, 16Shigh-salt dietimmunitymicrobiomewildling

Identifiers

PMID37049406
PMCPMC10096756
OpenAlexW4360862842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.