Evidence map›Paper›PMID 37049394›Full record

ArticleNutrients2023

Elevated Maternal Folate Status and Changes in Maternal Prolactin, Placental Lactogen and Placental Growth Hormone Following Folic Acid Food Fortification: Evidence from Two Prospective Pregnancy Cohorts.

Tanja Jankovic-Karasoulos, Melanie D Smith, Shalem Leemaqz, Jessica Williamson, Dylan McCullough, Anya L Arthurs, Lauren A Jones, Konstantinos Justin Bogias, Ben W Mol, Julia Dalton and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Tanja Jankovic-KarasoulosFlinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5000, Australia.
Melanie D SmithFlinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5000, Australia.ORCID 0000-0001-7016-8245
Shalem LeemaqzFlinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5000, Australia.
Jessica WilliamsonFlinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5000, Australia.
Dylan McCulloughFlinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5000, Australia.ORCID 0000-0002-4510-3797
Anya L ArthursFlinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5000, Australia.ORCID 0000-0002-4382-0610
Lauren A JonesFlinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5000, Australia.
Konstantinos Justin BogiasFlinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5000, Australia.
Ben W MolDepartment of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3800, Australia.
Julia DaltonLyell McEwin Hospital, Adelaide, SA 5112, Australia.
Gustaaf A DekkerLyell McEwin Hospital, Adelaide, SA 5112, Australia.
Claire T RobertsFlinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5000, Australia.ORCID 0000-0002-9250-2192
Flinders University · AULyell McEwin Hospital · AUMonash University · AU

Funding

National Health and Medical Research Council GNT1161079National Health and Medical Research Council GNT1174971
6 · The paper itself

Abstract

Folic acid (FA) food fortification in Australia has resulted in a higher-than-expected intake of FA during pregnancy. High FA intake is associated with increased insulin resistance and gestational diabetes. We aimed to establish whether maternal one-carbon metabolism and hormones that regulate glucose homeostasis change in healthy pregnancies post-FA food fortification. Circulating folate, B12, homocysteine, prolactin (PRL), human placental lactogen (hPL) and placental growth hormone (GH2) were measured in early pregnancy maternal blood in women with uncomplicated pregnancies prior to (SCOPE: N = 604) and post (STOP: N = 711)-FA food fortification. FA food fortification resulted in 63% higher maternal folate. STOP women had lower hPL (33%) and GH2 (43%) after 10 weeks of gestation, but they had higher PRL (29%) and hPL (28%) after 16 weeks. FA supplementation during pregnancy increased maternal folate and reduced homocysteine but only in the SCOPE group, and it was associated with 54% higher PRL in SCOPE but 28% lower PRL in STOP. FA food fortification increased maternal folate status, but supplements no longer had an effect, thereby calling into question their utility. An altered secretion of hormones that regulate glucose homeostasis in pregnancy could place women post-fortification at an increased risk of insulin resistance and gestational diabetes, particularly for older women and those with obesity.

Indexed as

Diabetes, GestationalInsulin ResistanceAgedFemaleFolic AcidFood, FortifiedGlucoseGrowth HormoneHumansPlacentaPlacental LactogenPregnancyProlactinProspective StudiesFolic AcidGlucoseGrowth HormonePlacental LactogenProlactinfolic acidgestational diabetes mellitushuman placental lactogenobesityplacental growth hormonepregnancyprolactin

Identifiers

PMID37049394
PMCPMC10097170
OpenAlexW4360615368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.