ArticleNanomaterials (Basel, Switzerland)2023
Biogenic Synthesis of Cu-Mn Bimetallic Nanoparticles Using Pumpkin Seeds Extract and Their Characterization and Anticancer Efficacy.
Article in Nanomaterials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Green synthesis of a manganese oxide-selenium nanocomposite using watermelon peel waste with antimicrobial and mosquitocidal activities.RSC advances · 2026Article
- Anticancer Potential of Cucurbitaceae, Brassicaceae, Liliaceae and Chenopodiaceae: A Review of In Vitro Evidence.Molecules (Basel, Switzerland) · 2026Review
- Synergetic anticancer activity of psidium guajava-mediated palladium nanoparticles via apoptosis induction and metastasis suppression in osteosarcoma cells.Scientific reports · 2026Article
- Fungal-mediated green synthesis of ZnO-MnO nanocomposites with antimicrobial and anticancer properties.Scientific reports · 2026Article
- Biogenic Silver-Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus.PloS one · 2026Article
- Article
- ZnO@Cu5.4O Nanoparticle Alleviates Inflammatory Responses of Intestinal Epithelial Cells by Inhibiting the Expression of GSDMB.ACS omega · 2025Article
- Phyto-assisted eco-benevolent synthesis of oxidase-mimic Cu-MnBioprocess and biosystems engineering · 2025Article
- STAT3 Signaling Pathway in Health and Disease.MedComm · 2025Review
- Exploring the anticancer potential of traditional herbs from Tamil Nadu: a narrative review of ethnomedicinal insights and scientific evidence.Frontiers in immunology · 2025Review
- Green Biosynthesis of Bimetallic Copper Oxide-Selenium Nanoparticles Using Leaf Extract ofInternational journal of nanomedicine · 2025Article
- Assessing the biomedical applicability of biogenically synthesized AuNPs using Salvia splendens extract.PloS one · 2025Article
- Biogenic gold nanoparticles synthesized fromOpen life sciences · 2025Article
- Biosynthesis of ZnO, BiChemistryOpen · 2024Article
- Eco-Friendly CuO/FeHeliyon · 2024Article
- Article
- One-step preparation, characterization, and anticancer potential of ZnFeSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Unveiling anticancer, antimicrobial, and antioxidant activities of novel synthesized bimetallic boron oxide-zinc oxide nanoparticles.RSC advances · 2023Article
- Green biosynthesis of bimetallic selenium-gold nanoparticles usingFrontiers in bioengineering and biotechnology · 2023Article
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Authors and funding
6 authors.
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Abstract
backgroundCancer is a chronic, heterogeneous illness that progresses through a spectrum of devastating clinical manifestations and remains the 2nd leading contributor to global mortality. Current cancer therapeutics display various drawbacks that result in inefficient management. The present study is intended to evaluate the anticancer potential of Cu-Mn bimetallic NPs (CMBNPs) synthesized from pumpkin seed extract against colon adenocarcinoma cancer cell line (HT-29).
methodsThe CMBNPs were biosynthesized by continuously stirring an aqueous solution of pumpkin seed extract with CuSO4 and manganese (II) acetate tetrahydrate until a dark green solution was obtained. The characteristic features of biogenic CMBNPs were assessed by UV-visible spectrophotometry (UV-vis), X-ray powder diffraction (XRD), energy-dispersive X-ray (EDX), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). A battery of biological assays, viz. neutral red uptake (NRU) assay, in vitro scratch assay, and comet assay, were performed for anticancer efficacy evaluation.
resultsThe formation of spherical monodispersed bimetallic nanoparticles with an average size of 50 nm was recorded using TEM. We observed dose-dependent cytotoxicity of CMBNPs in the HT-29 cell line with an IC
conclusionsThe results showed substantial anticancer efficacy of CMBNPs against the studied cancer cell line. However, it is advocated that the current work be expanded to different in vitro cancer models so that an in vivo validation could be carried out in the most appropriate cancer model.
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