ReviewMaterials (Basel, Switzerland)2023
Calcium Silicate-Based Sealer Dentinal Tubule Penetration-A Systematic Review of In Vitro Studies.
Review in Materials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mapping risk of bias criteria in systematic reviews of in vitro endodontic studies: an umbrella review.Evidence-based dentistry · 2025Pooled it
- Pooled it
- Comparative Dentinal Tubule Penetration of Three Calcium Silicate-Based Sealers Under Conventional and Sonic-Activated Final Irrigation Protocols: An In Vitro Confocal Microscopy Study.Dentistry journal · 2026Article
- [Study of the Sealing and Antibacterial Properties of Bioceramic Root Canal Sealers Modified With Quaternary Ammonium Salt].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Effects of Calcium Silicate-Based Sealer Residues on Adhesive Bonding to Coronal Dentin: An in Vitro Study.Journal of dental research, dental clinics, dental prospects · 2026Article
- Dentinal Tubule Penetration of an Endodontic Sealer in the Apical Third of Root Canals After Different Final Irrigation Techniques.Journal of clinical medicine · 2026Article
- Sealing Ability of Polydopamine-Coated Gutta-Percha With Bioceramic Sealer: An In Vitro Study.International journal of dentistry · 2026Article
- Article
- Osteogenic Potential of Various Premixed Hydraulic Calcium Silicate-Based Sealers on Human Bone Marrow Stem Cells.Materials (Basel, Switzerland) · 2025Article
- Dentinal tubule penetration of AH Plus, MTA Fillapex, and BioRoot flow: a confocal laser scanning microscopy study.BMC oral health · 2025Article
- Randomized Trial of Bioceramic Apical Barrier Methods in Necrotic Immature Incisors: Effects on Pain, Extrusion, and Procedure Duration.Children (Basel, Switzerland) · 2025Article
- Impact of cone system compatibility on single cone bioceramic obturation in canals prepared with variable taper NiTi rotary files.Scientific reports · 2025Article
- Sealing ability of the single-cone obturation technique with bioceramic sealer iRoot SP in oval root canals: an in vitro study.BMC oral health · 2025Article
- Evaluation the impact of access cavity design and activation of calcium silicate-based sealer with EDDY and XP-Endo Finisher on sealer penetration into dentinal tubules: a confocal laser scanning microscopy study.Head & face medicine · 2025Article
- Resistance of gutta-percha and calcium silicate-based sealer to dislocation after non-surgical root canal retreatment.BMC oral health · 2025Article
- Evaluation of the Effects of Retro-Cavity Preconditioning with or Without Ethylenediaminetetraacetic Acid on Root Surface pH and Dislodgement Resistance of NeoMTA2 and Mineral Trioxide Aggregate Flow Retro-Fills: An Ex Vivo Investigation.Journal of functional biomaterials · 2024Article
- Comparative Assessment of Push-Out Bond Strength and Dentinal Tubule Penetration of Different Calcium-Silicate-Based Endodontic Sealers.Dentistry journal · 2024Article
- Article
- Clinical outcome of non-surgical root canal treatment using different sealers and techniques of obturation in 237 patients: A retrospective study.Clinical oral investigations · 2024Article
- Interfacial adaptation of newly prepared nano-tricalcium silicate-58s bioactive glass-based endodontic sealer.Journal of dental research, dental clinics, dental prospects · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this systematic review was to perform a qualitative synthesis of in vitro studies which evaluate and compare the penetration of calcium silicate-based sealers into dentinal tubules. A systematic advanced search was performed in Scopus, Embase, Medline (via PubMed), Web of Science, and Cochrane databases on the 1 December 2022. In vitro studies that compared the tubular penetration of at least two calcium silicate-based sealers in extracted human teeth were eligible. PRILE 2021 guidelines were used for the assessment of the risk of bias included studies. The search identified a total of 680 preliminary records, among which 12 studies were eligible for review. The most used methodology to evaluate sealer penetration was the use of a fluorochrome together with the tested sealers and the analysis of their penetration under confocal laser microscopy. Regarding the results of the included studies, calcium silicate-based sealers exhibit a favorable dentinal tubule penetration. Tubular penetration, however, can be affected by factors such as the irrigation protocol, sealer activation, the filling method used, and root canal morphology. EndoSequence BC Sealer showed the highest sealer penetration among the tested sealers. The influence of different fluorochromes on the results of dentinal tubule penetration studies should also be further explored. The in vitro nature of the included studies limits the applicability of the results into the clinical setting. Prospero registration: CRD42022383896.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.