ArticleJournal of clinical medicine2023
The Impact of Nonmotor Symptoms on Health-Related Quality of Life in Parkinson's Disease: A Network Analysis Approach.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Glymphatic Dysfunction in Parkinson's Disease: A Systematic Review and Meta-Analysis of Neuroimaging Studies.Movement disorders clinical practice · 2026Pooled it
- The impact of bright light therapy on non-motor symptoms in patients with Parkinson's disease: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Comparative Safety of Istradefylline Among Parkinson Disease Adjunctive Therapies: A Systematic Review and Meta-analysis of Randomized Controlled Studies.Clinical neuropharmacologyPooled it
- Acupuncture and Sleep Quality Among Patients With Parkinson Disease: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Altered light-dark phase-dependent behavioral responses and suprachiasmatic nucleus pathology in an α-synuclein rat model of Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Impact of non-motor symptoms on the quality of life of Parkinson's disease patients in a cohort of Senegalese patients.BMC neurology · 2026Article
- Nonmotor Symptoms in Parkinson's Disease: Neurophysiology Biomarkers and Neuromodulation Approaches.Stereotactic and functional neurosurgery · 2026Review
- Sex-Specific Patterns of Taste Dysfunction, Their Relationships with α-Synuclein Profiling, and Supervised Learning-Based Diagnosis in Parkinson's Disease (PD).International journal of molecular sciences · 2026Article
- The Prevalence of Medically Unexplained Symptoms in Emergency Neurology Service.Medicina (Kaunas, Lithuania) · 2026Article
- Identification of Gene Signatures and Molecular Mechanisms for Diagnosing Parkinson's Disease and Nonalcoholic Fatty Liver Disease Using Machine Learning.Parkinson's disease · 2026Article
- Joint network analysis of non-motor symptoms and quality of life in patients with Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Effectiveness of Photobiomodulation to Treat Motor and Non-Motor Symptoms of Parkinson's Disease: A Randomised Clinical Trial with Extended Treatment.Journal of clinical medicine · 2025Article
- Effects of Exercise on Balance, Gait Speed, Quality of Life, and Symptom Relief Among Older Adults with Parkinson's Disease: A Meta-Analysis of Randomized Controlled Trials (RCTs).Healthcare (Basel, Switzerland) · 2025Review
- Assessment of Health-Related Quality of Life in Parkinson's Disease: A Systematic Review.Cureus · 2025Review
- Evidence for the Link Between Non-Motor Symptoms, Kinematic Gait Parameters, and Physical Function in People with Parkinson's Disease.Bioengineering (Basel, Switzerland) · 2025Article
- Article
- Targeting neuroplasticity: a viewpoint on a future research direction with Parkinson's disease-related fatigue.Frontiers in aging neuroscience · 2025Article
- Article
- Relative contribution of comorbid diseases to health-related quality of life in patients with Parkinson's disease.Journal of patient-reported outcomes · 2024Article
- Impact of depressive symptoms on medication adherence in older adults with chronic neurological diseases.BMC psychiatry · 2024Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Nonmotor symptoms negatively affect health-related quality of life (HRQoL) in patients with Parkinson's disease (PD). However, it is unknown which nonmotor symptoms are most commonly associated with HRQoL. Considering the complex interacting network of various nonmotor symptoms and HRQoL, this study aimed to reveal the network structure, explained HRQoL variance, and identify the nonmotor symptoms that primarily affect HRQoL. We included 689 patients with PD from the Cohort of Patients with Parkinson's Disease in Spain (COPPADIS) study who were rated on the Nonmotor Symptoms Scale in Parkinson's disease (NMSS) and the Parkinson´s Disease Questionnaire 39 (PDQ-39) at baseline. Network analyses were performed for the 30 items of the NMSS and both the PDQ-39 summary index and eight subscales. The nodewise predictability, edge weights, strength centrality, and bridge strength were determined. In PD, nonmotor symptoms are closely associated with the mobility, emotional well-being, cognition, and bodily discomfort subscales of the PDQ-39. The most influential nonmotor symptoms were found to be fatigue, feeling sad, hyperhidrosis, impaired concentration, and daytime sleepiness. Further research is needed to confirm whether influencing these non-motor symptoms can improve HRQoL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.