Evidence map›Paper›PMID 37048106›Full record

ArticleCells2023

Ectopic Rod Photoreceptor Development in Mice with Genetic Deficiency of WNT2B.

Alexandra K Blomfield, Meenakshi Maurya, Kiran Bora, Madeline C Pavlovich, Felix Yemanyi, Shuo Huang, Zhongjie Fu, Amy E O'Connell, Jing Chen

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Alexandra K BlomfieldDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0002-2550-477X
Meenakshi MauryaDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Kiran BoraDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Madeline C PavlovichDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Felix YemanyiDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0002-5017-555X
Shuo HuangDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Zhongjie FuDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0002-8182-2983
Amy E O'ConnellDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-9298-6991
Jing ChenDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Boston Children's Hospital · US

Funding

Dietary control of angiogenesis in retinopathy modelsR01EY017017 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Zhongjie Fu, Lois Smith · 2006 to 2026
$11.8M
RORalpha mediates chronic subretinal inflammation associated with AMDR01EY024963 · NEI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, JING · 2015 to 2025
$4.2M
Regulation of RPE degeneration by REV-ERBalphaR01EY031765 · NEI · BOSTON CHILDREN'S HOSPITAL · PI JING CHEN · 2020 to 2026
$2.7M
Wnt signaling-mediated control of blood-retinal barrierR01EY028100 · NEI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, JING · 2017 to 2021
$2.2M
Serine control of retinal neovascularization in retinopathyR01EY032492 · NEI · BOSTON CHILDREN'S HOSPITAL · PI FU, ZHONGJIE · 2021 to 2025
$2.2M
The Role of Wnt2b in Intestinal HealthK08DK120871 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI OCONNELL, AMY E · 2020 to 2024
$896k
NEI NIH HHS R01 EY017017NEI NIH HHS R01 EY024963NEI NIH HHS R01 EY028100NEI NIH HHS R01 EY031765NEI NIH HHS R01 EY032492NIDDK NIH HHS K08 DK120871
6 · The paper itself

Abstract

Wnt/β-catenin signaling is essential for embryonic eye development in both the anterior eye and retina. WNT2B, a ligand and activator of the Wnt/β-catenin pathway, assists in the development of the lens and peripheral regions of the eye. In humans

Indexed as

RetinaRetinal Rod Photoreceptor CellsWnt ProteinsAnimalsbeta CateninGlycoproteinsHumansMiceMice, KnockoutRetinal Pigment Epitheliumbeta CateninGlycoproteinsWnt2b protein, mouseWnt ProteinsdevelopmentphotoreceptorretinaWNT2BWnt signaling

Identifiers

PMID37048106
PMCPMC10093714
OpenAlexW4361209641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.