Evidence map›Paper›PMID 37048068›Full record

ArticleCells2023

Development of a Triple-Negative Breast Cancer Leptomeningeal Disease Model in Zebrafish.

Udhayakumar Gopal, Jerry D Monroe, Amarnath S Marudamuthu, Salma Begum, Bradley J Walters, Rodney A Stewart, Chad W Washington, Yann Gibert, Marcus A Zachariah

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Advancements in Zebrafish Models for Breast Cancer Research: Unveiling Biomarkers, Targeted Therapies, and Personalized Medicine.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Pooled it
  2. Targeting platelet-tumor cell interactions via thromboxane AExperimental hematology & oncology · 2025
    Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Udhayakumar GopalDepartment of Neurosurgery, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0003-2110-0601
Jerry D MonroeDepartment of Cell and Molecular Biology, Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Amarnath S MarudamuthuDepartment of Neurosurgery, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Salma BegumDepartment of Cell and Molecular Biology, Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Bradley J WaltersDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Rodney A StewartDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-1220-1830
Chad W WashingtonDepartment of Neurosurgery, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Yann GibertDepartment of Cell and Molecular Biology, Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0001-8208-7223
Marcus A ZachariahNeurosurgical Medical Clinic, 3750 Convoy Street, Suite 301, San Diego, CA 92111, USA.
University of Mississippi Medical Center · USUniversity of Utah · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2013 to 2022
$23.4M
Mechanisms responsible for tooth morphogenesis in vertebratesR01DE029803 · NIDCR · UNIVERSITY OF MISSISSIPPI MED CTR · PI GIBERT, YANN · 2021 to 2025
$1.8M
Developmental Mechanisms Driving Cell Invasion in Pediatric Brain CancersR01NS106527 · NINDS · UNIVERSITY OF UTAH · PI STEWART, RODNEY A. · 2018 to 2022
$1.7M
NIDCR NIH HHS R01 DE029803NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20 GM121334NIGMS NIH HHS U54 GM115428NINDS NIH HHS R01 NS106527
6 · The paper itself

Abstract

Leptomeningeal disease occurs when cancer cells migrate into the ventricles of the brain and spinal cord and then colonize the meninges of the central nervous system. The triple-negative subtype of breast cancer often progresses toward leptomeningeal disease and has a poor prognosis because of limited treatment options. This is due, in part, to a lack of animal models with which to study leptomeningeal disease. Here, we developed a translucent zebrafish

Indexed as

Antineoplastic AgentsTriple Negative Breast NeoplasmsAnimalsApoptosisDoxorubicinHumansZebrafishAntineoplastic AgentsDoxorubicindoxorubicinleptomeningeal diseasetriple-negative breast cancerxenograftzebrafish

Identifiers

PMID37048068
PMCPMC10093412
OpenAlexW4360852153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.