Evidence map›Paper›PMID 37048064›Full record

ArticleCells2023

Methemoglobinemia, Increased Deformability and Reduced Membrane Stability of Red Blood Cells in a Cat with a

Sophia Jenni, Odette Ludwig-Peisker, Vidhya Jagannathan, Sandra Lapsina, Martina Stirn, Regina Hofmann-Lehmann, Nikolay Bogdanov, Nelli Schetle, Urs Giger, Tosso Leeb and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Curcumin's Protective Effects Against HMolecules (Basel, Switzerland) · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. IndependentGenes · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sophia JenniClinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.ORCID 0009-0003-9577-5457
Odette Ludwig-PeiskerInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0003-0691-1211
Vidhya JagannathanInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Sandra LapsinaClinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
Martina StirnClinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
Regina Hofmann-LehmannClinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0001-9750-4296
Nikolay BogdanovRed Blood Cell Group, Institute of Veterinary Physiology and the Center for Clinical Studies, Vetsuisse Faculty Zurich, University of Zurich, 8057 Zurich, Switzerland.
Nelli SchetleRed Blood Cell Group, Institute of Veterinary Physiology and the Center for Clinical Studies, Vetsuisse Faculty Zurich, University of Zurich, 8057 Zurich, Switzerland.
Urs GigerClinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0002-4770-4107
Tosso LeebInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0003-0553-4880
Anna BogdanovaRed Blood Cell Group, Institute of Veterinary Physiology and the Center for Clinical Studies, Vetsuisse Faculty Zurich, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0003-0502-5381
University of Zurich · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methemoglobinemia is an acquired or inherited condition resulting from oxidative stress or dysfunction of the NADH-cytochrome b5 reductase or associated pathways. This study describes the clinical, pathophysiological, and molecular genetic features of a cat with hereditary methemoglobinemia. Whole genome sequencing and mRNA transcript analyses were performed in affected and control cats. Co-oximetry, ektacytometry, Ellman's assay for reduced glutathione concentrations, and CYB5R activity were assessed. A young adult European domestic shorthair cat decompensated at induction of anesthesia and was found to have persistent methemoglobinemia of 39 ± 8% (reference range < 3%) of total hemoglobin which could be reversed upon intravenous methylene blue injection. The erythrocytic CYB5R activity was 20 ± 6% of normal. Genetic analyses revealed a single homozygous base exchange at the beginning of intron 3 of the

Indexed as

MethemoglobinemiaAnimalsCatsErythrocytesGlutathioneMethylene BlueRNA, MessengerGlutathioneMethylene BlueRNA, Messengercyanosiserythrocytosisfelinehematologymicrocytosisprecision medicinered blood cellssplicing

Identifiers

PMID37048064
PMCPMC10093206
OpenAlexW4360856874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.