Evidence map›Paper›PMID 37048051›Full record

ArticleCells2023

STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.

Tracy L Hagemann, Sierra Coyne, Alder Levin, Liqun Wang, Mel B Feany, Albee Messing

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tracy L HagemannWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-0237-9267
Sierra CoyneWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Alder LevinWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Liqun WangWyss Institute, Harvard University, Boston, MA 02115, USA.
Mel B FeanyDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Albee MessingWaisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0001-6049-0521
University of Wisconsin–Madison · USBrigham and Women's Hospital · USHarvard University · US

Funding

Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2016 to 2020
$6.0M
Patient-derived iPS cells as model systems for AxDP01HD076892 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI NEDERGAARD, MAIKEN · 2014 to 2018
$6.0M
Astrocyte-synapse interactions in a rat model of Alexander diseaseR01NS110719 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI HAGEMANN, TRACY · 2019 to 2023
$2.1M
STAT3 and astrogliosis in Alexander diseaseR21NS093482 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI HAGEMANN, TRACY · 2015 to 2016
$421k
NICHD NIH HHS P01 HD076892NICHD NIH HHS P50 HD105353NICHD NIH HHS U54 HD090256NINDS NIH HHS R01 NS110719NINDS NIH HHS R21 NS093482
6 · The paper itself

Abstract

Alexander disease (AxD) is caused by mutations in the gene for glial fibrillary acidic protein (GFAP), an intermediate filament expressed by astrocytes in the central nervous system. AxD-associated mutations cause GFAP aggregation and astrogliosis, and GFAP is elevated with the astrocyte stress response, exacerbating mutant protein toxicity. Studies in mouse models suggest disease severity is tied to

Indexed as

Alexander DiseaseGlial Fibrillary Acidic ProteinSTAT3 Transcription FactorAnimalsAstrocytesDisease Models, AnimalHumansIntermediate FilamentsMiceMutationGlial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseSTAT3 protein, humanStat3 protein, mouseSTAT3 Transcription FactorAlexander diseaseastrocyteGFAPreactive gliosisRosenthal fibersSTAT3

Identifiers

PMID37048051
PMCPMC10093589
OpenAlexW4360614838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.