Evidence map›Paper›PMID 37047834›Full record

ArticleInternational journal of molecular sciences2023

Folic Acid Ameliorates Renal Injury in Experimental Obstructive Nephropathy: Role of Glycine N-Methyltransferase.

Ko-Lin Kuo, Chin-Wei Chiang, Yi-Ming Arthur Chen, Chih-Chin Yu, Tzong-Shyuan Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Ko-Lin KuoDivision of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231405, Taiwan.ORCID 0000-0002-7477-0388
Chin-Wei ChiangDepartment of Physiology, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Yi-Ming Arthur ChenGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei 24205, Taiwan.
Chih-Chin YuDivision of Urology, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231405, Taiwan.ORCID 0000-0002-1344-1505
Tzong-Shyuan LeeGraduate Institute, Department of Physiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0002-9593-4062
Tzu Chi University · TWFu Jen Catholic University · TWNational Taiwan University · TWNational Yang Ming Chiao Tung University · TW

Funding

Buddhist Tzu Chi Medical Foundation, Taiwan TCMF-EP 109-01, and TCMF-JCT 111-17National Science and Technology Council MOST 108-2314-B-303-006-MY3, 108-2320-B-002-032-MY3, 111-2320-B-002-016-MY3, and 111-2314-B-303-017-MY3Taipei Tzu Chi Hospital CRD-TPE-MOST-109-08 and TCRD-TPE-111-07 (1/3)
6 · The paper itself

Abstract

Folic acid exerts both anti-inflammatory and antifibrotic effects. Glycine N-methyltransferase (GNMT), the major folic acid-binding protein in the liver, is a crucial enzyme that regulates the cellular methylation process by maintaining S-adenosylmethionine levels. However, as yet neither the therapeutic effects of folic acid in renal fibrosis nor whether GNMT is involved in these folic acid-associated mechanisms has been investigated. First, the expression of GNMT was examined in human kidneys with or without obstructive nephropathy. Later, wild-type and

Indexed as

Glycine N-MethyltransferaseKidney DiseasesUreteral ObstructionAnimalsFibrosisFolic AcidHumansKidneyLiverMiceS-AdenosylmethionineFolic AcidGlycine N-MethyltransferaseGNMT protein, humanGnmt protein, mouseS-Adenosylmethioninefolic acidglycine N-methyltransferaseunilateral ureteral obstruction

Identifiers

PMID37047834
PMCPMC10095475
OpenAlexW4362665819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.