Evidence map›Paper›PMID 37047792›Full record

ArticleInternational journal of molecular sciences2023

To Target or Not to Target

Yang Zheng, Susanne Schroeder, Georgi K Kanev, Sanaa S Botros, Samia William, Abdel-Nasser A Sabra, Louis Maes, Guy Caljon, Carmen Gil, Ana Martinez and 11 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Discovery of an Orally Efficacious Pyrazolo[3,4-Journal of medicinal chemistry · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 5 countries.

Yang ZhengDivision of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Susanne SchroederSchool of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Georgi K KanevDivision of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Sanaa S BotrosPharmacology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza 12411, Egypt.
Samia WilliamParasitology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza 12411, Egypt.ORCID 0000-0002-0521-1734
Abdel-Nasser A SabraPharmacology Department, Theodor Bilharz Research Institute, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza 12411, Egypt.
Louis MaesLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.ORCID 0000-0002-2324-9509
Guy CaljonLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.ORCID 0000-0002-4870-3202
Carmen GilCentro de Investigaciones Biologicas (CIB-CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.ORCID 0000-0002-3882-6081
Ana MartinezCentro de Investigaciones Biologicas (CIB-CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.ORCID 0000-0002-2707-8110
Irene G SaladoMedicinal Chemistry, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.
Koen AugustynsMedicinal Chemistry, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.ORCID 0000-0002-5203-4339
Ewald EdinkDivision of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Maarten SijmDivision of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Erik de HeuvelDivision of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Iwan J P de EschDivision of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Tiffany van der MeerDivision of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Marco SideriusDivision of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Geert Jan SterkDivision of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
David BrownSchool of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Rob LeursDivision of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.ORCID 0000-0003-1354-2848
Vrije Universiteit Amsterdam · NLUniversity of Antwerp · BETheodor Bilharz Research Institute · EGCentro de Investigaciones Biológicas Margarita Salas · ESUniversity of Kent · GB

Funding

China Scholarship Council 201506220185European Union 602666
6 · The paper itself

Abstract

Schistosomiasis is a neglected tropical disease with high morbidity. Recently, the

Indexed as

Phosphodiesterase 4 InhibitorsSchistosomiasisAminopyridinesAnimalsBenzamidesCyclic Nucleotide Phosphodiesterases, Type 4CyclopropanesHumansNucleotides, CyclicSchistosoma mansoniAminopyridinesBenzamidesCyclic Nucleotide Phosphodiesterases, Type 4CyclopropanesNucleotides, CyclicPhosphodiesterase 4 InhibitorsRoflumilastdrug targetphosphodiesteraseSchistosoma mansoni

Identifiers

PMID37047792
PMCPMC10095301
OpenAlexW4362668562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.