ReviewInternational journal of molecular sciences2023
Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Effect of norepinephrine reuptake inhibitors combined with antimuscarinic agents vs monotherapy for OSA: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Pooled it
- Effect of inflammatory cytokines and plasma metabolome on OSA: a bidirectional two- sample Mendelian randomization study and mediation analysis.Frontiers in immunology · 2024Pooled it
- Trial
- Sleep disturbances, inflammation, and muscle function in older adults with sarcopenia.Sleep & breathing = Schlaf & Atmung · 2026Article
- Circulating IGFBP-7 in Obstructive Sleep Apnea: A Single-Cohort Preliminary Assessment of Its Diagnostic Performance and Post-Treatment Dynamics.Biomedicines · 2026Article
- The interconnection between obstructive sleep apnoea and spondyloarthritis: pathophysiology, clinical evidence, and future perspectives.Rheumatology international · 2026Review
- Obstructive Sleep Apnea in Critically Ill Patients: A Structured Narrative Review of Prevalence, Diagnostic Barriers, and Clinical Implications in the ICU.Clocks & sleep · 2026Review
- Mitochondrial dysfunction in sleep deprivation.Metabolic brain disease · 2026Review
- Obstructive Sleep Apnea in Patients with Significant Coronary Artery Disease: An Underdiagnosed Condition.Journal of clinical medicine · 2026Article
- Hyperbaric Oxygen Therapy and Its Physio-Mechanical Effects on Sleep Breathing Disorder: A Systematic Review.Pulmonary therapy · 2026Review
- Linking sleep apnea and arthritis in the National Alzheimer Coordinating Center Cohort: A cross-sectional analysis.Medicine · 2026Article
- Sleep Quality as a Predictor of Coronary Artery Disease Severity in Geriatric Acute Coronary Syndrome.Medicina (Kaunas, Lithuania) · 2026Observational
- Obstructive sleep apnea risk is associated with a diminished cognitive profile: findings from the Canadian longitudinal study on aging.Frontiers in psychology · 2026Article
- Plasma ALKBH5 depletion during severe intermittent hypoxia and its attenuation by galectin-3 inhibition: an experimental rat study.Frontiers in cardiovascular medicine · 2026Article
- Body mass index mediates the association between children's dietary inflammatory index and obstructive sleep apnea-hypopnea syndrome in children: a cross-sectional study.Frontiers in public health · 2026Article
- A multi-perspective interpretative phenomenological analysis of patient and bed partner experiences with CPAP therapy adaptation in obstructive sleep apnoea.Scientific reports · 2025Article
- Therapeutic nutrition strategies for the shared pathophysiology of obesity and sleep-disordered breathings.Nutrition journal · 2025Review
- Impact of obstructive sleep apnea severity and treatment on COVID-19 vaccine-induced immune responses.Journal of thoracic disease · 2025Article
- Role of Free Radicals in the Pathophysiology of OSA: A Narrative Review of a Double-Edged Sword.Journal of clinical medicine · 2025Review
- Programmed cell death in the cognitive impairment of obstructive sleep apnea.Cell & bioscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnoea (OSA) is a prevalent underdiagnosed disorder whose incidence increases with age and weight. Uniquely characterised by frequent breathing interruptions during sleep-known as intermittent hypoxia (IH)-OSA disrupts the circadian rhythm. Patients with OSA have repeated episodes of hypoxia and reoxygenation, leading to systemic consequences. OSA consequences range from apparent symptoms like excessive daytime sleepiness, neurocognitive deterioration and decreased quality of life to pathological complications characterised by elevated biomarkers linked to endocrine-metabolic and cardiovascular changes. OSA is a well-recognized risk factor for cardiovascular and cerebrovascular diseases. Furthermore, OSA is linked to other conditions that worsen cardiovascular outcomes, such as obesity. The relationship between OSA and obesity is complex and reciprocal, involving interaction between biological and lifestyle factors. The pathogenesis of both OSA and obesity involve oxidative stress, inflammation and metabolic dysregulation. The current medical practice uses continuous positive airway pressure (CPAP) as the gold standard tool to manage OSA. It has been shown to improve symptoms and cardiac function, reduce cardiovascular risk and normalise biomarkers. Nonetheless, a full understanding of the factors involved in the deleterious effects of OSA and the best methods to eliminate their occurrence are still poorly understood. In this review, we present the factors and evidence linking OSA to increased risk of cardiovascular conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.