Evidence map›Paper›PMID 37047730›Full record

ArticleInternational journal of molecular sciences2023

The Impact of

Marlene Santos, Luis Lima, Serafim Carvalho, Jorge Mota-Pereira, Paulo Pimentel, Dulce Maia, Diana Correia, M Fátima Barroso, Sofia Gomes, Agostinho Cruz and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. International journal of molecular sciences · 2024
    Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Marlene SantosCentro de Investigação em Saúde e Ambiente (CISA), Escola Superior de Saúde, Instituto Politécnico do Porto, 4200-072 Porto, Portugal.
Luis LimaExperimental Pathology and Therapeutics Group, IPO-Porto Research Center (CI-IPOP), Portuguese Institute of Oncology, 4200-072 Porto, Portugal.
Serafim CarvalhoHospital de Magalhães Lemos, 4149-003 Porto, Portugal.ORCID 0000-0002-6181-0096
Jorge Mota-PereiraClínica Médico-Psiquiátrica da Ordem, 4000-270 Porto, Portugal.
Paulo PimentelTrás-os-Montes e Alto Douro Hospital Centre, 5000-508 Vila Real, Portugal.
Dulce MaiaTrás-os-Montes e Alto Douro Hospital Centre, 5000-508 Vila Real, Portugal.
Diana CorreiaHospital de Magalhães Lemos, 4149-003 Porto, Portugal.
M Fátima BarrosoREQUIMTE/LAQV, Instituto Superior de Engenharia do Instituto Politécnico do Porto, 4200-072 Porto, Portugal.ORCID 0000-0001-9011-5992
Sofia GomesHospital de Magalhães Lemos, 4149-003 Porto, Portugal.
Agostinho CruzCentro de Investigação em Saúde e Ambiente (CISA), Escola Superior de Saúde, Instituto Politécnico do Porto, 4200-072 Porto, Portugal.ORCID 0000-0002-1157-8196
Rui MedeirosMolecular Oncology & Viral Pathology, IPO-Porto Research Center (CI-IPOP), Portuguese Institute of Oncology, 4200-072 Porto, Portugal.ORCID 0000-0003-3010-8373
Hospital de Magalhães Lemos · PTInstituto Português de Oncologia Francisco Gentil · PTUnidade Local de Saúde de Trás-os-Montes e Alto Douro · PTOrdem dos Médicos · PTPolytechnic Institute of Porto · PTPortuguese League Against Epilepsy · PTRede de Química e Tecnologia · PT

Funding

AstraZeneca Fondation GENEDEP_09
6 · The paper itself

Abstract

This study aimed to investigate the influence of genetic variants in neuroplasticity-related genes on antidepressant treatment phenotypes. The BDNF-TrkB signaling pathway, as well as the downstream kinases Akt and ERK and the mTOR pathway, have been implicated in depression and neuroplasticity. However, clinicians still struggle with the unpredictability of antidepressant responses in depressed patients. We genotyped 26 polymorphisms in

Indexed as

Antidepressive AgentsMajor Depressive DisorderBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinGlycogen Synthase Kinase 3 betaHumansMitogen-Activated Protein Kinase 1Nerve Tissue ProteinsPhenotypePolymorphism, Single NucleotideProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseReceptors, Nerve Growth FactorRecurrenceTOR Serine-Threonine KinasesAntidepressive AgentsBrain-Derived Neurotrophic FactorCREB1 protein, humanCyclic AMP Response Element-Binding ProteinGlycogen Synthase Kinase 3 betaGSK3B protein, humanMAPK1 protein, humanMitogen-Activated Protein Kinase 1MTOR protein, humanNerve Tissue ProteinsNGFR protein, humanProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePTEN protein, humanReceptors, Nerve Growth FactorTOR Serine-Threonine KinasesADBDNFgenetic polymorphismsGSK3BMAPKneuroplasticityPTENSYN1treatment-resistant depression

Identifiers

PMID37047730
PMCPMC10095078
OpenAlexW4362620113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.