Evidence map›Paper›PMID 37047715›Full record

ArticleInternational journal of molecular sciences2023

Local Microtubule and F-Actin Distributions Fully Constrain the Spatial Geometry of

Sumit Nanda, Shatabdi Bhattacharjee, Daniel N Cox, Giorgio A Ascoli

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sumit NandaCenter for Neural Informatics, Structures, and Plasticity and Neuroscience Program, Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA.
Shatabdi BhattacharjeeNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Daniel N CoxNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0001-9191-9212
Giorgio A AscoliCenter for Neural Informatics, Structures, and Plasticity and Neuroscience Program, Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA.
George Mason University · USGeorgia State University · US

Funding

Anatomical characterization of neuronal cell types of the mouse brainU01MH114829 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ASCOLI, GIORGIO A, DONG, HONG-WEI · 2017 to 2021
$13.9M
Generation and Description of Neuronal Morphology and ConnectivityR01NS039600 · NINDS · GEORGE MASON UNIVERSITY · PI ASCOLI, GIORGIO A · 1999 to 2024
$6.9M
Cytoskeletal mechanisms of dendrite arbor shape developmentR01NS086082 · NINDS · GEORGIA STATE UNIVERSITY · PI ASCOLI, GIORGIO A, COX, DANIEL N · 2013 to 2023
$3.1M
NIH HHS NIH R01 NS39600 and NS086082NIMH NIH HHS U01 MH114829NINDS NIH HHS R01 NS039600NINDS NIH HHS R01 NS086082
6 · The paper itself

Abstract

Dendritic morphology underlies the source and processing of neuronal signal inputs. Morphology can be broadly described by two types of geometric characteristics. The first is dendrogram topology, defined by the length and frequency of the arbor branches; the second is spatial embedding, mainly determined by branch angles and straightness. We have previously demonstrated that microtubules and actin filaments are associated with arbor elongation and branching, fully constraining dendrogram topology. Here, we relate the local distribution of these two primary cytoskeletal components with dendritic spatial embedding. We first reconstruct and analyze 167 sensory neurons from the

Indexed as

DrosophilaDrosophila ProteinsActin CytoskeletonActinsAnimalsDendritesMicrotubulesSensory Receptor CellsActinsDrosophila Proteinsactin filamentarbor geometrybranch anglebranch straightnesscomputational modellingdendritic arborization neuronsDrosophila larvamicrotubulemutated morphologyneuron morphology

Identifiers

PMID37047715
PMCPMC10095360
OpenAlexW4362633929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.